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Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.

Autor: Czikora A; From the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Lundberg DJ; Department of Science, Technology, and Mathematics, Gallaudet University, Washington, D. C. 20002, and., Abramovitz A; From the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Lewin NE; From the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Kedei N; From the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Peach ML; Basic Science Program, Leidos Biomedical Research, Inc., Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702., Zhou X; From the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Merritt RC Jr; Department of Science, Technology, and Mathematics, Gallaudet University, Washington, D. C. 20002, and., Craft EA; Department of Science, Technology, and Mathematics, Gallaudet University, Washington, D. C. 20002, and., Braun DC; Department of Science, Technology, and Mathematics, Gallaudet University, Washington, D. C. 20002, and., Blumberg PM; From the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, blumberp@dc37a.nci.nih.gov.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 May 20; Vol. 291 (21), pp. 11133-47. Date of Electronic Publication: 2016 Mar 28.