Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli

Autor: Jakob Frimodt-Møller, Andreas Koulouktsis, Godefroid Charbon, Marit Otterlei, Peter E. Nielsen, Anders Løbner-Olesen

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 444-454 (2021)

Cell-penetrating peptides (CPPs) are increasingly used for cellular drug delivery in both pro- and eukaryotic cells, and oligoarginines have attracted special attention. How arginine-rich CPPs translocate across the cell envelope, particularly for pr

Externí odkaz: https://doaj.org/article/253da9a6a4314fa899fff9d789465764

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A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane

Autor: Kerrie L. May, Kelly M. Lehman, Angela M. Mitchell, Marcin Grabowicz

Publikováno v: mBio, Vol 10, Iss 3 (2019)

ABSTRACT Gram-negative bacteria produce lipid-anchored lipoproteins that are trafficked to their outer membrane (OM). These lipoproteins are essential components in each of the molecular machines that build the OM, including the Bam machine that asse

Externí odkaz: https://doaj.org/article/7cbc509f760b4c7ea83e858cf69fcb8c

Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli

Autor: Anders Løbner-Olesen, Jakob Frimodt-Møller, Godefroid Charbon, Peter E. Nielsen, Andreas Koulouktsis, Marit Otterlei

Publikováno v: Frimodt-Møller, J, Koulouktsis, A, Charbon, G, Otterlei, M, Nielsen, P E & Løbner-Olesen, A 2021, ' Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli ', Molecular Therapy-Nucleic Acids, vol. 25, pp. 444-454 . https://doi.org/10.1016/j.omtn.2021.06.009
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 444-454 (2021)
Molecular Therapy-Nucleic Acids

Cell-penetrating peptides (CPPs) are increasingly used for cellular drug delivery in both pro- and eukaryotic cells, and oligoarginines have attracted special attention. How arginine-rich CPPs translocate across the cell envelope, particularly for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cb366ef132e0eebada6d87b9dca3ac
https://curis.ku.dk/ws/files/280896670/Activating_the_Cpx_response_induces_tolerance_to_antisense_PNA_delivered_by_an_arginine_rich_peptide_in_Escherichia_coli.pdf

Emerging Roles for NlpE as a Sensor for Lipoprotein Maturation and Transport to the Outer Membrane in Escherichia coli

Autor: Brent W. Simpson, M. Stephen Trent

Publikováno v: mBio
mBio, Vol 10, Iss 3 (2019)
mBio, Vol 10, Iss 3, p e01302-19 (2019)

The outer membrane built by Gram-negative bacteria such as Escherichia coli forms a barrier that prevents antibiotics from entering the cell, limiting clinical options at a time of prevalent antibiotic resistance. Stress responses ensure that barrier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40f0aa4f2ef4a9927723c7b0f41daee
https://pubmed.ncbi.nlm.nih.gov/31138744