Zobrazeno 1 - 10
of 15 919
pro vyhledávání: '"CpG site"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background DNA methylation is a biochemical process in which a methyl group is added to the cytosine-phosphate-guanine (CpG) site on DNA molecules without altering the DNA sequence. Multiple CpG sites in a certain genome region can be differ
Externí odkaz:
https://doaj.org/article/d4158361311b4e2a91f018d2f270bd5c
Autor:
Chenglong Yu, Allison M Hodge, Ee Ming Wong, Jihoon E Joo, Enes Makalic, Daniel F Schmidt, Daniel D Buchanan, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugué
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1838-1847 (2022)
Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether genetic predisposition to tobacco smoking, alcohol consumption, and higher body mass index (BMI) moderates the effect of
Externí odkaz:
https://doaj.org/article/7c18175c47c8433e906f51d2875295f1
Akademický článek
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Autor:
Sheila T. Nagamatsu, Gregory Rompala, Yasmin L. Hurd, Diana L. Núñez-Rios, Janitza L. Montalvo-Ortiz, Traumatic Stress Brain Research Group, Victor E. Alvarez, David Benedek, Alicia Che, Dianne A. Cruz, David A. Davis, Matthew J. Girgenti, Ellen Hoffman, Paul E. Holtzheimer, Bertrand R. Huber, Alfred Kaye, John H. Krystal, Adam T. Labadorf, Terence M. Keane, Mark W. Logue, Ann McKee, Brian Marx, Deborah Mash, Mark W. Miller, Crystal Noller, JM-O, William K. Scott, Paula Schnurr, Thor Stein, Robert Ursano, Douglas E. Williamson, Erika J. Wolf, Keith A. Young
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
IntroductionDNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites. DNAm at non-CpG sites (mCpHs, where H in
Externí odkaz:
https://doaj.org/article/8e534560e2b9492589d5919efc931441
Akademický článek
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Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 3174-3187 (2020)
Abstract To improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification of hub methylated‐CpG sites and associated genes, weighted gene comethylation network analysis (WGCNA) was performed to examine and i
Externí odkaz:
https://doaj.org/article/da804876cb8d4f9f98c1db69d4b89dfb
Akademický článek
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Autor:
Tomohiro Hosoya, Masamichi Takahashi, Calvin Davey, Jun Sese, Mai Honda-Kitahara, Yasuji Miyakita, Makoto Ohno, Shunsuke Yanagisawa, Takaki Omura, Daisuke Kawauchi, Yukie Ozeki, Miyu Kikuchi, Tomoyuki Nakano, Akihiko Yoshida, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura, Yoshitaka Narita
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1379 (2022)
The aim of the present study was to determine which individual or combined CpG sites among O6-methylguanine DNA methyltransferase CpG 74–89 in glioblastoma mainly affects the response to temozolomide resulting from CpG methylation using statistical
Externí odkaz:
https://doaj.org/article/b3d3b004e156448c896aaac5b70f88ae
Autor:
Ye Cao, Mari J. Tokita, Edward S. Chen, Rajarshi Ghosh, Tiansheng Chen, Yanming Feng, Elizabeth Gorman, Federica Gibellini, Patricia A. Ward, Alicia Braxton, Xia Wang, Linyan Meng, Rui Xiao, Weimin Bi, Fan Xia, Christine M. Eng, Yaping Yang, Tomasz Gambin, Chad Shaw, Pengfei Liu, Pawel Stankiewicz
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Although mosaic variation has been known to cause disease for decades, high-throughput sequencing technologies with the analytical sensitivity to consistently detect variants at reduced allelic fractions have only recently emerged
Externí odkaz:
https://doaj.org/article/86ee908a71bb4a7ab56d4cd217c72cb4
Autor:
Ji Hu, Fu-ying Zhao, Bin Huang, Jing Ran, Mei-yuan Chen, Hai-lin Liu, You-song Deng, Xia Zhao, Xiao-fan Han
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
AimTo develop and validate a CpG-based classifier for preoperative discrimination of early and advanced-late stage colorectal cancer (CRC).MethodsWe identified an epigenetic signature based on methylation status of multiple CpG sites (CpGs) from 372
Externí odkaz:
https://doaj.org/article/7b2bc2f68fe743c7a7a32f22f3018ab8