Zobrazeno 1 - 10
of 1 186
pro vyhledávání: '"CpG Island Methylator Phenotype"'
Autor:
Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z. Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, Jean-Pierre J. Issa
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-infiltrating
Externí odkaz:
https://doaj.org/article/2856375f622b4bc5bda4e07109ea89fe
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101461- (2024)
Colorectal cancer (CRC) is a complicated illness caused by a mix of hereditary and environmental factors. It is one of the most common malignancies worldwide, yet it is also one of the most curable if detected early. There are three types of molecula
Externí odkaz:
https://doaj.org/article/a594d66f3b9a476d986c1012cada4b9c
Akademický článek
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Autor:
Pengfei Gu, Yu Zeng, Weike Ma, Wei Zhang, Yu Liu, Fengli Guo, Xianhui Ruan, Jiadong Chi, Xiangqian Zheng, Ming Gao
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
CpG island methylator phenotype (CIMP), characterized by the concurrent and widespread hypermethylation of a cluster of CpGs, has been reported to play an important role in carcinogenesis. Limited studies have explored the role of CIMP in papillary t
Externí odkaz:
https://doaj.org/article/bc4651b5a7144559b0474ccaa436b965
Autor:
Yoshiki Okita, Minoru Koi, Koki Takeda, Ryan Ross, Bhramar Mukherjee, Erika Koeppe, Elena M. Stoffel, Joseph A. Galanko, Amber N. McCoy, Temitope O. Keku, Yoshinaga Okugawa, Takahito Kitajima, Yuji Toiyama, Eric Martens, John M. Carethers
Publikováno v:
Gut Pathogens, Vol 12, Iss 1, Pp 1-5 (2020)
Abstract Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP). Fn infect
Externí odkaz:
https://doaj.org/article/99ec52fbc04644c492b5dea7f470933d
Autor:
Melanie Ehrlich
Publikováno v:
Epigenetics, Vol 14, Iss 12, Pp 1141-1163 (2019)
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-malignant diseases. This is consistent with numerous findings about differentiation-associated changes in DNA methylation at promoters, enhancers, gene bodies, an
Externí odkaz:
https://doaj.org/article/d0b627c27eaa4058bb53299a04817d6b
Kniha
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Autor:
Jiang Liu, Li Tang, Jinhua Yi, Guimei Li, Youwang Lu, Yu Xu, Shuhua Zhao, Rui Mao, Xiaolu Li, Li Ren, Kunhua Wang
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutatio
Externí odkaz:
https://doaj.org/article/055e12da3bbd4793874516aef07295a6
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background The application of circulating, cell-free, methylated Septin9 (mSEPT9) DNA in screening and recurrence monitoring is highly promising. CpG island methylator phenotype (CIMP) is associated with microsatellite instability (MSI). The
Externí odkaz:
https://doaj.org/article/d6b2ab1c9c3b4f6db7602f1e1b228d2d
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
With the aging of the population, the incidence of colorectal cancer in China is increasing. One of the epigenetic alterations: CpG island methylator phenotype (CIMP) plays an important role in the incidence of colorectal cancer. Recent studies have
Externí odkaz:
https://doaj.org/article/365b19b415e94a46bc7a8f19d3ca22b5