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ALDH1A3 is the switch that determines the balance of ALDH ⁺ and CD24 ^- CD44 ⁺ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.

Autor: Fernando W; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Biology, Acadia University, Wolfville, NS, Canada., Cruickshank BM; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Surgery, Dalhousie University, Halifax, NS, Canada., Arun RP; Department of Pathology, Dalhousie University, Halifax, NS, Canada., MacLean MR; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Cahill HF; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Morales-Quintanilla F; Department of Biology, Faculty of Science, Saint Mary's University, Halifax, NS, Canada., Dean CA; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Wasson MD; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Dahn ML; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Coyle KM; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Walker OL; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Power Coombs MR; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Biology, Acadia University, Wolfville, NS, Canada., Marcato P; Department of Pathology, Dalhousie University, Halifax, NS, Canada. paola.marcato@dal.ca.; Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada. paola.marcato@dal.ca.; Nova Scotia Health Authority, Halifax, NS, Canada. paola.marcato@dal.ca.

Publikováno v: Oncogene [Oncogene] 2024 Oct; Vol. 43 (43), pp. 3151-3169. Date of Electronic Publication: 2024 Sep 09.

Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma.

Autor: Sircar A; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Singh S; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Xu-Monette ZY; Division of Hematopathology, Department of Pathology, Duke University Medical Center, Durham, NC, USA., Coyle KM; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Hilton LK; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada., Chavdoula E; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Ranganathan P; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Jain N; Division of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India., Hanel W; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Tsichlis P; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Alinari L; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Peterson BR; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Tao J; Division of Pathology, University of Virginia, Charlottesville, VA, USA., Muthusamy N; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Baiocchi R; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Epperla N; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA., Young KH; Division of Hematopathology, Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Duke Cancer Institute, Durham, NC, USA., Morin R; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada.; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer, Vancouver, BC, Canada., Sehgal L; Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH, USA. Lalit.Sehgal@osumc.edu.; The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA. Lalit.Sehgal@osumc.edu.

Publikováno v: Leukemia [Leukemia] 2023 Oct; Vol. 37 (10), pp. 2094-2106. Date of Electronic Publication: 2023 Aug 19.

A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours.

Autor: Nohara LL; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Ellis SLS; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Dreier C; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Dada S; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Saranchova I; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Bok Choi K; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada., Munro L; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Al Haddad E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada., Pfeifer CG; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Coyle KM; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Morrice JR; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada., Shim DJS; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Ahn P; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., De Voogd N; Netherlands Centre for Biodiversity Naturalis, Leiden, Netherlands., Williams DE; Departments of Chemistry and Earth Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Cheng P; Departments of Chemistry and Earth Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Garrovillas E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada., Andersen RJ; Departments of Chemistry and Earth Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Jefferies WA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 May 15; Vol. 14, pp. 1119607. Date of Electronic Publication: 2023 May 15 (Print Publication: 2023).