Structure-guided design of purine-based probes for selective Nek2 inhibition

Autor: Coxon, CR, Wong, C, Bayliss, RWA, Boxall, K, Carr, KH, Fry, AM, Hardcastle, IR, Matheson, CJ, Newell, DR, Sivaprakasam, M, Thomas, H, Turner, D, Yeoh, S, Wang, LZ, Griffin, RJ, Golding, BT, Cano, C

Publikováno v: Oncotarget

Nek2 (NIMA-related kinase 2) is a cell cycle-dependent serine/threonine protein kinase that regulates centrosome separation at the onset of mitosis. Overexpression of Nek2 is common in human cancers and\ud suppression can restrict tumor cell growth a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2a81c9e348a99e3a06a93c16991f5ec9

Structure-guided design of purine-based probes for selective Nek2 inhibition

Autor: Coxon, CR

Nek2 (NIMA-related kinase 2) is a cell cycle-dependent serine/threonine protein kinase that regulates centrosome separation at the onset of mitosis. Overexpression of Nek2 is common in human cancers and suppression can restrict tumor cell growth and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::48617ef6ec011a64ba3e6a89d0ce1d9e

Fluorinated Tags to Study Protein Conformation and Interactions Using ¹⁹ F NMR.

Autor: Hanson GSM; EaStChem School of Chemistry, University of Edinburgh, Joseph Black Building, Kings Buildings, West Mains Road, EH9 3FJ, Edinburgh, UK., Coxon CR; EaStChem School of Chemistry, University of Edinburgh, Joseph Black Building, Kings Buildings, West Mains Road, EH9 3FJ, Edinburgh, UK.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Aug 01; Vol. 25 (15), pp. e202400195. Date of Electronic Publication: 2024 Jun 24.

Novel peptide calcitonin gene-related peptide antagonists for migraine therapy.

Autor: Killoran PM; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom., Capel V; NHS Health Education England, Victoria House, Fulbourn, Cambridge, CB21 5XB, United Kingdom., D'Aloisio V; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom.; AmbioPharm, Inc., 1024 Dittman Court, North Augusta, SC 29842, United States., Schofield A; EaStCHEM School of Chemistry, The University of Edinburgh, Joseph Black Building, David, Brewster Road, Edinburgh, EH14 4AS, United Kingdom., Aczél T; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, Szigeti út 12, Pécs, Hungary.; Eötvös Lorand Research Network, Chronic Pain Research Group, University of Pécs, Szigeti út 12, Pécs, Hungary., Bölcskei K; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, Szigeti út 12, Pécs, Hungary.; Eötvös Lorand Research Network, Chronic Pain Research Group, University of Pécs, Szigeti út 12, Pécs, Hungary., Helyes Z; Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, Szigeti út 12, Pécs, Hungary.; Eötvös Lorand Research Network, Chronic Pain Research Group, University of Pécs, Szigeti út 12, Pécs, Hungary.; PharmInVivo Ltd., Szondi Gy. u. 10. H-7629, Pécs, Hungary.; National Laboratory for Drug Research and Development, Magyar tudósok krt. 2, H-1117 Budapest, Hungary., von Mentzer B; Innovipharm Limited, 2 Woodlands Lane, West Kirby, Wirral, CH48 8D, United Kingdom., Kendall DA; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom.; Innovipharm Limited, 2 Woodlands Lane, West Kirby, Wirral, CH48 8D, United Kingdom., Coxon CR; EaStCHEM School of Chemistry, The University of Edinburgh, Joseph Black Building, David, Brewster Road, Edinburgh, EH14 4AS, United Kingdom., Hutcheon GA; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom.

Publikováno v: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2023 Dec 08; Vol. 75 (12), pp. 1581-1589.

Probing Peptidylprolyl Bond cis/trans Status Using Distal ¹⁹ F NMR Reporters.

Autor: Killoran PM; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, Merseyside, L3 3AF, UK., Hanson GSM; EaStChem School of Chemistry, The University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH14 4AS, UK., Verhoork SJM; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, Merseyside, L3 3AF, UK., Smith M; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, Merseyside, L3 3AF, UK., Del Gobbo D; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, Merseyside, L3 3AF, UK., Lian LY; Institute of Systems, Molecular and Integrative Biology, The University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK., Coxon CR; EaStChem School of Chemistry, The University of Edinburgh Joseph Black Building, David Brewster Road, Edinburgh, EH14 4AS, UK.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Mar 16; Vol. 29 (16), pp. e202203017. Date of Electronic Publication: 2023 Feb 16.