Zobrazeno 1 - 10
of 713
pro vyhledávání: '"Coxibs"'
Autor:
Miguel A. Zuqui-Ramírez, Victor M. Belalcazar-López, Adelfia Urenda-Quezada, Alejandro González-Rebatu y González, José G. Sander-Padilla, Laura A. Lugo-Sánchez, Ileana C. Rodríguez-Vázquez, Kevin F. Rios-Brito, María M. Arguedas-Núñez, Emmanuel Canales-Vázquez, Jorge González-Canudas
Publikováno v:
Pain and Therapy, Vol 13, Iss 6, Pp 1511-1528 (2024)
Abstract Introduction Pain and disability management are crucial for a speedy recovery. Combining analgesics with different mechanisms of action provides greater pain relief with lower doses, promoting efficient multimodal analgesia. This study evalu
Externí odkaz:
https://doaj.org/article/fd8fd8ea89274e0290d6d8636bd6acc8
Autor:
Alessandra Ammazzalorso, Stefania Tacconelli, Annalisa Contursi, Ulrika Hofling, Carmen Cerchia, Sara Di Berardino, Alessandra De Michele, Rosa Amoroso, Antonio Lavecchia, Paola Patrignani
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundPPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an anal
Externí odkaz:
https://doaj.org/article/5c7eb75e16cc4e4bb13aaa4e81dd9bb1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Paweł Gumułka, Łukasz Pecio, Paweł Żmudzki, Krzesimir Ciura, Krystyna Skalicka-Woźniak, Monika Dąbrowska, Małgorzata Starek
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2609 (2023)
Determining the influence of environmental factors on the stability of drugs is very helpful when choosing excipients, storage conditions or packaging materials. In addition, information about possible toxic degradation products enables detecting and
Externí odkaz:
https://doaj.org/article/4e57c6130c8c4400bd393883041f3f5c
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-9 (2021)
Abstract Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase-2 (COX-2) inhibitors used to tr
Externí odkaz:
https://doaj.org/article/2f946116f0e140e1a93b949ce866061d
Autor:
Aleksandra Majchrzak-Celińska, Julia O. Misiorek, Nastassia Kruhlenia, Lukasz Przybyl, Robert Kleszcz, Katarzyna Rolle, Violetta Krajka-Kuźniak
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-18 (2021)
Abstract Background Glioblastoma (GBM) is the deadliest and the most common primary brain tumor in adults. The invasiveness and proliferation of GBM cells can be decreased through the inhibition of Wnt/β-catenin pathway. In this regard, celecoxib is
Externí odkaz:
https://doaj.org/article/a2cc76bcb11e4d9489f8b73501b6fd1f
Publikováno v:
Journal of Inflammation Research, Vol Volume 14, Pp 253-263 (2021)
Gopa Mahesh, Kotha Anil Kumar, Pallu Reddanna Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, IndiaCorrespondence: Pallu Reddanna Tel +91-40-23134542Email preddanna@gmail.comAbstract: Inflammation is
Externí odkaz:
https://doaj.org/article/bfcd628dde3a4c4fb225c41e59b955f1
Autor:
Sandy Lemm, Susanne Köhler, Robert Wodtke, Friedrich Jung, Jan-Heiner Küpper, Jens Pietzsch, Markus Laube
Publikováno v:
Cells, Vol 11, Iss 15, p 2447 (2022)
The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability,
Externí odkaz:
https://doaj.org/article/7972334a5b5c4f9ab2b41f50fec351b0
Autor:
Afaf A. El-Malah, Magdy M. Gineinah, Pran Kishore Deb, Ahdab N. Khayyat, Monika Bansal, Katharigatta N. Venugopala, Anfal S. Aljahdali
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 827 (2022)
The introduction of selective COX-2 inhibitors (so-called ‘coxibs’) has demonstrated tremendous commercial success due to their claimed lower potential of serious gastrointestinal adverse effects than traditional NSAIDs. However, following the re
Externí odkaz:
https://doaj.org/article/8c7629413e8f42de88fed1fd3dfed592
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.