A novel whole "Joint-in-Motion" device reveals a permissive effect of high glucose levels and mechanical stress on joint destruction.

Autor: Hui Mingalone CK; Program in Cell, Molecular, and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA., Nehme CR; Department of Mechanical Engineering, Tufts University, Medford, MA 02155, USA., Chen Y; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA., Liu J; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Longo BN; Department of Mechanical Engineering, Tufts University, Medford, MA 02155, USA., Garvey KD; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA., Covello SM; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA., Nielsen HC; Program in Cell, Molecular, and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA; Department of Pediatrics, Tufts Medical Center, Boston, MA 02111, USA., James T; Department of Mechanical Engineering, Tufts University, Medford, MA 02155, USA., Messner WC; Department of Mechanical Engineering, Tufts University, Medford, MA 02155, USA. Electronic address: bmessner@andrew.cmu.edu., Zeng L; Program in Cell, Molecular, and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: Li.Zeng@tufts.edu.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2023 Apr; Vol. 31 (4), pp. 493-506. Date of Electronic Publication: 2022 Nov 12.