Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Autor: Evans, Dm, Spencer, Cc, Pointon, Jj, Su, Z, Harvey, D, Kochan, G, Oppermann, U, Dilthey, A, Pirinen, M, Stone, Ma, Appleton, L, Moutsianas, L, Leslie, S, Wordsworth, T, Kenna, Tj, Karaderi, T, Thomas, Gp, Ward, Mm, Weisman, Mh, Farrar, C, Bradbury, La, Danoy, P, Inman, Rd, Maksymowych, W, Gladman, D, Rahman, P, Spondyloarthritis Research Consortium of Canada, Morgan, A, Marzo Ortega, H, Bowness, P, Gaffney, K, Gaston, Js, Smith, M, Bruges Armas, J, Couto, Ar, Sorrentino, Rosa, Paladini, Fabiana, Ferreira, Ma, Xu, H, Liu, Y, Jiang, L, Lopez Larrea, C, Díaz Peña, R, López Vázquez, A, Zayats, T, Band, G, Bellenguez, C, Blackburn, H, Blackwell, Jm, Bramon, E, Bumpstead, Sj, Casas, Jp, Corvin, A, Craddock, N, Deloukas, P, Dronov, S, Duncanson, A, Edkins, S, Freeman, C, Gillman, M, Gray, E, Gwilliam, R, Hammond, N, Hunt, Se, Jankowski, J, Jayakumar, A, Langford, C, Liddle, J, Markus, Hs, Mathew, Cg, Mccann, Ot, Mccarthy, Mi, Palmer, Cn, Peltonen, L, Plomin, R, Potter, Sc, Rautanen, A, Ravindrarajah, R, Ricketts, M, Samani, N, Sawcer, Sj, Strange, A, Trembath, Rc, Viswanathan, Ac, Waller, M, Weston, P, Whittaker, P, Widaa, S, Wood, Nw, Mcvean, G, Reveille, Jd, Wordsworth, Bp, Brown, Ma, Donnelly, P, Australo Anglo American Spondyloarthritis Consortium, Wellcome Trust Case Control Consortium, 2

Publikováno v: Nature genetics. 43(8)

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3c0b68fc466f3736958ce5c23edb4e
https://pubmed.ncbi.nlm.nih.gov/21808290

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Corrigendum: Evidence for a genetic contribution to the ossification of spinal ligaments in ossification of posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis: a narrative review.

Autor: Couto AR; Hospital de Santo Espirito da Ilha Terceira EPER, SEEBMO, Angra do Heroísmo, Portugal.; Comprehensive Health Research Centre, Hospital de Santo Espírito da Ilha Terceira, Lisbon, Portugal., Parreira B; Hospital de Santo Espirito da Ilha Terceira EPER, SEEBMO, Angra do Heroísmo, Portugal.; Comprehensive Health Research Centre, Hospital de Santo Espírito da Ilha Terceira, Lisbon, Portugal., Power DM; University of Algarve, Center of Marine Science (CCMAR), Faro, Portugal., Pinheiro L; Hospital de Santo Espirito da Ilha Terceira EPER, Orthopedics Service, Angra do Heroísmo, Portugal., Madruga Dias J; Centro Hospitalar Do Medio Tejo EPE Unidade de Torres Novas, Rheumatology Department, Santarém, Portugal.; CHRC Campus Nova Medical School, EpiDoc Research Unit, CEDOC, Lisboa, Portugal., Novofastovski I; Emek Medical Center, Rheumatology Unit, Afula, Israel., Eshed I; Sheba Medical Center, Tel Aviv, Israel., Sarzi-Puttini P; Luigi Sacco University Hospital, Rheumatology Unit, Milano, Italy., Pappone N; Istituti Clinici Scientifici Maugeri IRCCS, Neuromotor Rehabilitation Unit of Telese Terme Institute, Pavia, Italy., Atzeni F; Universita Degli Studi di Messina, Rheumatology Unit, Clinical and Experimental Medicine, Messina, Italy., Verlaan JJ; University Medical Centre, Department of Orthopedics, Utrecht, Netherlands., Kuperus J; Universitair Medisch Centrum Utrecht, Utrecht, Netherlands., Bieber A; Emek Medical Center, Rheumatology Unit, Afula, Israel., Ambrosino P; Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation Unit of Telese Terme Institute, Pavia, Italy., Kiefer D; Ruhr-Universitat Bochum, Rheumazentrum Ruhrgebiet, Bochum, Germany., Khan MA; Case Western Reserve University, Cleveland, OH, United States., Mader R; Emek Medical Center, Rheumatology Unit, Afula, Israel.; Rappaport Faculty of Medicine, Technion, Haifa, Israel.; Ruhr University Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany., Baraliakos X; Ruhr University Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany., Bruges-Armas J; Hospital de Santo Espirito da Ilha Terceira EPER, SEEBMO, Angra do Heroísmo, Portugal.; Comprehensive Health Research Centre, Hospital de Santo Espírito da Ilha Terceira, Lisbon, Portugal.

Publikováno v: Frontiers in genetics [Front Genet] 2024 Aug 30; Vol. 15, pp. 1477788. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).