Zobrazeno 1 - 10
of 1 083
pro vyhledávání: '"Coussens, P"'
Autor:
Thomas S. Dexheimer, Nathan P. Coussens, Thomas Silvers, Eric M. Jones, Li Chen, Jianwen Fang, Joel Morris, Jeffrey A. Moscow, James H. Doroshow, Beverly A. Teicher
Publikováno v:
SLAS Discovery, Vol 29, Iss 7, Pp 100186- (2024)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates genes of drug transporters and metabolic enzymes to detoxify small molecule xenobiotics. It has a complex role in cancer biology, influencing both the progr
Externí odkaz:
https://doaj.org/article/d5d6e57234014b9b957345d8f7354e31
Publikováno v:
Frontiers in Sports and Active Living, Vol 6 (2024)
IntroductionIndoor cycling at home has grown rapidly in recent years facilitated by advances in technology and gamification. However, there is limited data on individual's training practices when cycling indoors.MethodsUsing a single-time point, cros
Externí odkaz:
https://doaj.org/article/4900c52760bc47d19f7fe517961ee821
Autor:
Sushil Kumar, Dhanir Tailor, Arpit Dheeraj, Wenqi Li, Kirsten Stefan, Jee Min Lee, Dylan Nelson, Bailey F. Keefe, Pepper Schedin, Shivaani Kummar, Lisa M. Coussens, Sanjay V. Malhotra
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101698- (2024)
Summary: Tumor-associated macrophages (TAMs) and other myelomonocytic cells are implicated in regulating responsiveness to immunotherapies, including immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis. We have developed an ex vivo high
Externí odkaz:
https://doaj.org/article/cfaf32627f2d4969978c0e42493daa35
Autor:
Emma S. Chambers, Weigang Cai, Giulia Vivaldi, David A. Jolliffe, Natalia Perdek, Wenhao Li, Sian E. Faustini, Joseph M. Gibbons, Corinna Pade, Alex G. Richter, Anna K. Coussens, Adrian R. Martineau
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Vaccine development targeting SARS-CoV-2 in 2020 was of critical importance in reducing COVID-19 severity and mortality. In the U.K. during the initial roll-out most individuals either received two doses of Pfizer COVID-19 vaccine (BNT162b2)
Externí odkaz:
https://doaj.org/article/2bf8b9f303d3489cb53fdb91aa74388d
Autor:
Cyrus Cooper, David A Jolliffe, Adrian R Martineau, Linda-Gail Bekker, Nicholas C Harvey, William D Fraser, Keren Middelkoop, Jonathan Tang, Anna K Coussens, Robert J Wilkinson, Neil Walker, Lisa Micklesfield, Justine Stewart, Amy E Mendham, James Nuttall, Waheedullah Momand
Publikováno v:
BMJ Paediatrics Open, Vol 8, Iss 1 (2024)
Objective To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.Design Phase 3 double-blind randomised placebo-controlled trial.Set
Externí odkaz:
https://doaj.org/article/07f8e889db6445a88839aa69107c9b5e
Autor:
Katie D. Dale, Alvaro Schwalb, Anna K. Coussens, Katherine B. Gibney, Alison J. Abboud, Krista Watts, Justin T. Denholm
Publikováno v:
European Respiratory Review, Vol 33, Iss 173 (2024)
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb). Following infection, immune responses to Mtb antigens can be measured using the tuberculin skin test or an interferon-γ release assay. The gain of Mtb immunoreactivity, a change from a
Externí odkaz:
https://doaj.org/article/3d776482b7ed4da1ba6db19bc20daaa4
Autor:
Aneta Pluta, Tasia Marie Taxis, Frank van der Meer, Sulav Shrestha, Dominic Qualley, Paul Coussens, Marzena Rola-Łuszczak, Anna Ryło, Ali Sakhawat, Saltanat Mamanova, Jacek Kuźmak
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), which has been reported worldwide. The expression of viral structural proteins: surface glycoprotein (gp51) and three core proteins - p15 (matrix), p24 (ca
Externí odkaz:
https://doaj.org/article/f86b7bbca1f446ddb818576c69e43ebd
Autor:
Coussens, Stephen, Spiess, Jann
Instrumental variables (IV) regression is widely used to estimate causal treatment effects in settings where receipt of treatment is not fully random, but there exists an instrument that generates exogenous variation in treatment exposure. While IV c
Externí odkaz:
http://arxiv.org/abs/2108.03726
Autor:
Coussens, Thomas, Gialopsou, Aikaterini, Abel, Christopher, Bason, Mark G., James, Tim M., Evans, William, Woodley, Michael T. M., Nicolau, Denilson, Page, Leigh, Orucevic, Fedja, Kruger, Peter
To address the demands in healthcare and industrial settings for spatially resolved magnetic imaging, we present a modular optically pumped magnetometer (OPM) system comprising a multi-sensor array of highly sensitive quantum magnetometers. This syst
Externí odkaz:
http://arxiv.org/abs/2106.05877
Autor:
Zinab O. Doha, Xiaoyan Wang, Nicholas L. Calistri, Jennifer Eng, Colin J. Daniel, Luke Ternes, Eun Na Kim, Carl Pelz, Michael Munks, Courtney Betts, Sunjong Kwon, Elmar Bucher, Xi Li, Trent Waugh, Zuzana Tatarova, Dylan Blumberg, Aaron Ko, Nell Kirchberger, Jennifer A. Pietenpol, Melinda E. Sanders, Ellen M. Langer, Mu-Shui Dai, Gordon Mills, Koei Chin, Young Hwan Chang, Lisa M. Coussens, Joe W. Gray, Laura M. Heiser, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop
Externí odkaz:
https://doaj.org/article/2f5efa1be7d149bcb492c236e0e02ed5