Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Courtney T. Griffin"'
Autor:
Xiang Ma, Wenjing Wu, Miwa Hara, Junwen Zhou, Carolina Panzarin, Christopher M. Schafer, Courtney T. Griffin, Jiyang Cai, Jian-Xing Ma, Yusuke Takahashi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Subretinal fibrosis permanently impairs the vision of patients with neovascular age-related macular degeneration. Despite emerging evidence revealing the association between disturbed metabolism in retinal pigment epithelium (RPE) and subret
Externí odkaz:
https://doaj.org/article/a7a841382f8940329f588c4556e2530c
Autor:
Yao Tong, Yinga Wu, Jing Ma, Masataka Ikeda, Tomomi Ide, Courtney T. Griffin, Xi-Qin Ding, Shusheng Wang
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102840- (2023)
Oxidative stress is hypothesized to drive the progression of age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cell layer is important for supporting the function of retina and is particularly susceptible to oxidative stress-in
Externí odkaz:
https://doaj.org/article/8830ae66ac4241448579582d132df8e7
Autor:
Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin, Roberto J. Pezza
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes. Chromatin remodeling complexes regulate critical proce
Externí odkaz:
https://doaj.org/article/c1b5f783da0046c2a172b472b0f8f3c6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In this work, we sought to investigate the direct effects of proinflammatory mediators on lymphatic endothelial cell (LEC) capillaries and whether they might induce regression. Our laboratory has developed novel in-vitro, serum-free, lymphatic tubulo
Externí odkaz:
https://doaj.org/article/22d2bc3458374b619a596444e53a036f
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 1 (2020)
Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage necroptosis. However, RIPK3 has been connected to numerous other cellular pathways, which raises ques
Externí odkaz:
https://doaj.org/article/fd3a506be9174593973b21737d371013
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253519 (2021)
The receptor-interacting protein kinase 3 (RIPK3) is a multi-functional protein best known for facilitating cellular necroptosis and inflammation. Recent evidence from our lab indicates that RIPK3 expression must be tightly regulated in endothelial c
Externí odkaz:
https://doaj.org/article/dcbecacf4371497d9d497a8de5be278a
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235799 (2020)
ATP-dependent chromatin-remodeling complexes epigenetically modulate transcription of target genes to impact a variety of developmental processes. Our lab previously demonstrated that CHD4-a central ATPase and catalytic enzyme of the NuRD chromatin-r
Externí odkaz:
https://doaj.org/article/988308b481f941a8b208b577477cf589
Autor:
Christopher M. Schafer, Silvia Martin-Almedina, Katarzyna Kurylowicz, Neil Dufton, Lourdes Osuna-Almagro, Meng-Ling Wu, Charmain F. Johnson, Aarti V. Shah, Dorian O. Haskard, Andrianna Buxton, Erika Willis, Kate Wheeler, Sean Turner, Magdalena Chlebicz, Rizaldy P. Scott, Susan Kovats, Audrey Cleuren, Graeme M. Birdsey, Anna M. Randi, Courtney T. Griffin
Publikováno v:
bioRxiv
BackgroundDuring infectious diseases, pro-inflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526ae34af15f04eccb276895f65dccd1
https://doi.org/10.1101/2023.02.08.527788
https://doi.org/10.1101/2023.02.08.527788
Autor:
Matthew Menendez, Anna Drozd, Katarzyna Borawska, Joanna J. Chmielewska, Meng-Ling Wu, Courtney T. Griffin
Publikováno v:
Circ Res
Background:The chromatin-remodeling enzyme BRG1 (brahma-related gene 1) regulates gene expression in a variety of rapidly differentiating cells during embryonic development. However, the critical genes that BRG1 regulates during lymphatic vascular de
Autor:
Gretchen M. Koller, George E. Davis, Kalia N. Aguera, Scott S. Kemp, Prisca K. Lin, Courtney T. Griffin, Jun Xie, Jocelynda Salvador
Publikováno v:
Am J Pathol
Whether alterations in the microtubule cytoskeleton affect the ability of endothelial cells (ECs) to sprout and form branching networks of tubes was investigated in this study. Bioassays of human EC tubulogenesis, where both sprouting behavior and lu