Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Courtney Stanton"'
1
Continuous Twin Screw Wet Granulation and Drying—Control Strategy for Drug Product Manufacturing
Autor: Pirjo Tajarobi, Gabriella Dahlgren, Brendon Ricart, Courtney Stanton, Eric Simone, Vibha Puri, Gurjit Bajwa, Jason Melnick
Publikováno v: Journal of Pharmaceutical Sciences. 108:3502-3514
The use of continuous manufacturing has been increasing within the pharmaceutical industry over the last few years. Continuous direct compression has been the focus of publications on the topic to date. The use of wet granulation can improve segregat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956c2fd2d116c943d8cba4700fde126d
https://doi.org/10.1016/j.xphs.2019.06.023
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2
Design space determination and process optimization in at-scale continuous twin screw wet granulation
Autor: Thomas F. O’Connor, Brendon Ricart, Sau L. Lee, Courtney Stanton, Luke Verdi, Huolong Liu, Brandye Smith-Goettler, Seongkyu Yoon
Publikováno v: Computers & Chemical Engineering. 125:271-286
At-scale industrial continuous twin screw wet granulation process was analyzed and optimized via design of experiment (DoE). The Box-Behnken method was selected to investigate the influence of key process variables on granule properties and tablet pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cbc718f045806ae4e817536ec1ef332
https://doi.org/10.1016/j.compchemeng.2019.03.026
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6
Benchmarking pKa Prediction Methods for Residues in Proteins
Autor: Courtney Stanton, Kendall N. Houk
Publikováno v: Journal of Chemical Theory and Computation. 4:951-966
Methods for estimation of pKa values of residues in proteins were tested on a set of benchmark proteins with experimentally known pKa values. The benchmark set includes 80 different residues (20 each for Asp, Glu, Lys, and His), half of which consist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9099558c0b18d542f288bb9ab3f0b43
https://doi.org/10.1021/ct8000014
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7
QM/MM Metadynamics Study of the Direct Decarboxylation Mechanism for Orotidine-5‘-monophosphate Decarboxylase Using Two Different QM Regions: Acceleration Too Small To Explain Rate of Enzyme Catalysis
Autor: Courtney Stanton, Christopher J. Mundy, I-F. William Kuo, Kendall N. Houk, Teodoro Laino
Publikováno v: The Journal of Physical Chemistry B. 111:12573-12581
Despite decades of study, the mechanism by which orotidine-5'-monophosphate decarboxylase (ODCase) catalyzes the decarboxylation of orotidine monophosphate remains unresolved. A computational investigation of the direct decarboxylation mechanism has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a21a440f1ad4a47045e069a6900b410
https://doi.org/10.1021/jp074858n
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8
Steiner Trees and 3-D Macromolecular Conformation
Autor: Courtney Stanton, J. MacGregor Smith
Publikováno v: INFORMS Journal on Computing. 16:470-485
One of the key issues in biochemistry and molecular modelling is the determination of 3-D minimum-energy configurations (MECs) for macromolecular structures such as proteins and DNA. Steiner minimal trees are seen as a useful algorithmic paradigm for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::125a80b16868f0f54a3e9244ab2af282
https://doi.org/10.1287/ijoc.1040.0101
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