Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Courtney Segovis"'
Autor:
Connor H. O’ Meara, Lucy A. Coupland, Farzaneh Kordbacheh, Benjamin J. C. Quah, Chih-Wei Chang, David A. Simon Davis, Anna Bezos, Anna M. Browne, Craig Freeman, Dillon J. Hammill, Pradeep Chopra, Gergely Pipa, Paul D. Madge, Esther Gallant, Courtney Segovis, Angela F. Dulhunty, Leonard F. Arnolda, Imogen Mitchell, Levon M. Khachigian, Ross W. Stephens, Mark von Itzstein, Christopher R. Parish
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp
Externí odkaz:
https://doaj.org/article/47652de3a653433fb4ea511fb90437ea
Autor:
Paul D. Madge, Gergely Pipa, Dillon J. Hammill, Pradeep Chopra, Benjamin J. C. Quah, Anna Bezos, David Anak Simon Davis, Lucy A. Coupland, Angela F. Dulhunty, Levon M. Khachigian, Christopher R. Parish, Farzaneh Kordbacheh, Connor H. O’ Meara, Imogen Mitchell, Ross W. Stephens, Mark von Itzstein, Courtney Segovis, Chih-Wei Chang, Esther M. Gallant, Leonard F Arnolda, Craig Freeman, Anna Browne
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by DNases. We report the development of small polyanions (SPAs) (~0.9–1.4 kDa) that interact e