Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Courtney S, Malo"'
1
Akademický článek
Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance
Autor: Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz: https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
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2
Akademický článek
Zika virus spreads through infection of lymph node-resident macrophages
Autor: Glennys V. Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael S. Diamond, Theodore C. Pierson, Heather D. Hickman
Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112126- (2023)
Summary: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells. However, the timing and mechanisms underlying shuttling of the virus by immune cells remains
Externí odkaz: https://doaj.org/article/1e565ee0ec8c4a429c99464dca821ac4
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3
Akademický článek
Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain
Autor: Emma N. Goddery, Cori E. Fain, Chloe G. Lipovsky, Katayoun Ayasoufi, Lila T. Yokanovich, Courtney S. Malo, Roman H. Khadka, Zachariah P. Tritz, Fang Jin, Michael J. Hansen, Aaron J. Johnson
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders are thought to mediate T cell entry into the parenchyma during neu
Externí odkaz: https://doaj.org/article/443b39ecb46d4a36a05a01c787ee7c3d
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5
Akademický článek
Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
Autor: Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko, Aaron J. Johnson
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to
Externí odkaz: https://doaj.org/article/7bf1f249199b44a48e774d5c33748d09
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Plný text Recenzováno Digitální knihovna AV ČR
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