Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge

Autor: Daniel Malouli, Meenakshi Tiwary, Roxanne M. Gilbride, David W. Morrow, Colette M. Hughes, Andrea Selseth, Toni Penney, Priscila Castanha, Megan Wallace, Yulia Yeung, Morgan Midgett, Connor Williams, Jason Reed, Yun Yu, Lina Gao, Gabin Yun, Luke Treaster, Amanda Laughlin, Jeneveve Lundy, Jennifer Tisoncik-Go, Leanne S. Whitmore, Pyone P. Aye, Faith Schiro, Jason P. Dufour, Courtney R. Papen, Husam Taher, Louis J. Picker, Klaus Früh, Michael Gale, Nicholas J. Maness, Scott G. Hansen, Simon Barratt-Boyes, Douglas S. Reed, Jonah B. Sacha

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if lung-resident effe

Externí odkaz: https://doaj.org/article/30aee6ee13914e60b17c02c57c123179

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

Autor: Justin M. Greene, Renee G. Espinosa Trethewy, Abigail B. Ventura, Husam Taher, Brian Berkemeier, Luke S. Uebelhoer, Jay A. Nelson, Finn Grey, Colette M. Hughes, Rebecca Shoemaker, Daniel Malouli, Courtney R. Papen, William J. Bosche, Louis J. Picker, David Morrow, Meaghan H. Hancock, Roxanne M. Gilbride, Michael Hull, Michael K. Axthelm, Julia C. Ford, Paul T. Edlefsen, Jonah B. Sacha, Daniel N. Streblow, Kurt T. Randall, Jason Shao, Scott G. Hansen, Jeffrey D. Lifson, Kelli Oswald, Matthew R. McArdle, Klaus Früh

Publikováno v: Malouli, D, Hansen, S G, Hancock, M H, Hughes, C M, Ford, J C, Gilbride, R M, Ventura, A B, Morrow, D, Randall, K T, Taher, H, Uebelhoer, L S, McArdle, M R, Papen, C R, Espinosa Trethewy, R, Oswald, K, Shoemaker, R, Berkemeier, B, Bosche, W J, Hull, M, Greene, J M, Axthelm, M K, Shao, J, Edlefsen, P T, Grey, F, Nelson, J A, Lifson, J D, Streblow, D, Sacha, J B, Früh, K & Picker, L J 2021, ' Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy ', Science Immunology, vol. 6, no. 57, eabg5413 . https://doi.org/10.1126/sciimmunol.abg5413

Simian immunodeficiency virus (SIV) insert-expressing, 68-1 Rhesus Cytomegalovirus (RhCMV/SIV) vectors elicit major histocompatibility complex (MHC)-E- and -II-restricted, SIV-specific CD8+ T cell responses, but the basis of these unconventional resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6054cac299f3617d6d4f213b423984f
https://doi.org/10.1101/2020.09.30.321349

Oregon Health & Science University (OHSU) Researchers Update Current Study Findings on Avian Influenza (Bird Flu) (Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized...).

Publikováno v: Vaccine Weekly; 8/9/2024, p303-303, 1p