Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Courtney R. Benoit"'
Autor:
Vicky Chou, Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Throug
Externí odkaz:
https://doaj.org/article/9e3d8cd8d32347f6b00af0ac1594f3b7
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, II, Alexandra M. Lish, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Mariko F. Taga, Kevin Huynh, Matthias Arnold, Peter J. Meikle, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112994- (2023)
Summary: SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte
Externí odkaz:
https://doaj.org/article/911ab12d4ed045b69c2a0c7474867a7a
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Hans-Ulrich Klein, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
bioRxiv
SummarySORL1 is strongly implicated in the pathogenesis of Alzheimer’s disease (AD) through human genetic studies that point to an association of reduced SORL1 levels with higher risk for AD. To interrogate the role(s) of SORL1 in human brain cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ca35d64f619357003633b6b32402a
https://doi.org/10.1101/2023.02.25.530017
https://doi.org/10.1101/2023.02.25.530017
Autor:
Darren J Walsh, Abigail Stanton, Courtney R. Benoit, Levan Mekerishvili, Nadia Houerbi, David M. McGaughey, Lawrence C. Brody
Publikováno v:
J Nutr
BACKGROUND: In humans, vitamin B-12 (cobalamin) transport involves 3 paralogous proteins: transcobalamin, haptocorrin, and intrinsic factor. Zebrafish (Danio rerio) express 3 genes that encode proteins homologous to known B-12 carrier proteins: tcn2
Autor:
Andrew R. Motzer, Stephen R. Bond, Lawrence C. Brody, Aileen C. Tartanian, Abigail Stanton, Courtney R. Benoit, David M. McGaughey
Publikováno v:
Journal of Biological Chemistry. 293:17606-17621
In humans, transport of food-derived cobalamin (vitamin B12) from the digestive system into the bloodstream involves three paralogous proteins: transcobalamin (TC), haptocorrin (HC), and intrinsic factor (IF). Each of these proteins contains two doma
Autor:
Valentina N. Lagomarsino, Vilas Menon, Courtney R. Benoit, Tracy L. Young-Pearse, Scott Noggle, Hyo Lee, Daniel Paull, Lei Liu, Maria A. Vicent, Marty A. Fernandez, Duc M. Duong, Christina Muratore, Monica Zhou, Daniel Felsky, Vicky Chou, Jonathan M.S. Stricker, Fatmata Bah, Dennis J. Selkoe, Seeley B. Fancher, Badri N. Vardarajan, Shinya Tasaki, Chris Gaiteri, Jishu Xu, Amy He, Yi-Chen Hsieh, Philip L. De Jager, Julie P. Merchant, Eric B. Dammer, Nicholas T. Seyfried, Richard V. Pearse, Allan I. Levey, Elizabeth A. Vinton, Hector Martinez, David A. Bennett, Lori B. Chibnik
Publikováno v:
Neuron
We have generated a controlled and manipulable resource that captures genetic risk for Alzheimer’s disease: iPSC lines from 53 individuals coupled with RNA and proteomic profiling of both iPSC-derived neurons and from brain tissue of the same indiv
Autor:
Courtney R, Benoit, Abigail E, Stanton, Aileen C, Tartanian, Andrew R, Motzer, David M, McGaughey, Stephen R, Bond, Lawrence C, Brody
Publikováno v:
The Journal of biological chemistry. 293(45)
In humans, transport of food-derived cobalamin (vitamin B(12)) from the digestive system into the bloodstream involves three paralogous proteins: transcobalamin (TC), haptocorrin (HC), and intrinsic factor (IF). Each of these proteins contains two do