Prognostic significance of the urokinase plasminogen activator system in tissue and serum of dogs with appendicular osteosarcoma.

Autor: Arata Matsuyama, Geoffrey A Wood, Rachael Speare, Courtney R Schott, Anthony J Mutsaers

Publikováno v: PLoS ONE, Vol 17, Iss 9, p e0273811 (2022)

Urokinase plasminogen activator (uPA) and its receptor uPAR promote cancer invasion and metastasis and are emerging therapeutic targets in both human and canine malignancies. While their clinical significance is well-characterized in multiple human t

Externí odkaz: https://doaj.org/article/8794e96cddc84fc3a556ec7afc4d25e8

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma

Autor: Kim Wong, Louise van der Weyden, Courtney R. Schott, Alastair Foote, Fernando Constantino-Casas, Sionagh Smith, Jane M. Dobson, Elizabeth P. Murchison, Hong Wu, Iwei Yeh, Douglas R. Fullen, Nancy Joseph, Boris C. Bastian, Rajiv M. Patel, Inigo Martincorena, Carla Daniela Robles-Espinoza, Vivek Iyer, Marieke L. Kuijjer, Mark J. Arends, Thomas Brenn, Paul W. Harms, Geoffrey A. Wood, David J. Adams

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Mucosal melanoma is a rare melanoma subtype that is poorly characterised. Here, the authors sequenced human, canine, and equine melanoma samples and performed a cross-species analysis, which revealed candidate driver genes, recurrent copy number alte

Externí odkaz: https://doaj.org/article/4e13d3e9fe6547238116ebda7ade7244

Abstract A51: STING activation overcomes immune escape in osteosarcoma metastasis

Autor: Elizabeth P Young, Courtney R Schott, Amanda Koehne, Christine Johnson, E. Alejandro Sweet-Cordero

Publikováno v: Cancer Immunology Research. 10:A51-A51

Chromosomal instability (CIN) has been known to be a hallmark of cancer for decades, but how CIN influences the tumor microenvironment (TME) and defines the ability of tumors to metastasize is a fundamental question in cancer biology that remains una

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b830afe02d709d0d10097429c4e5ffd8
https://doi.org/10.1158/2326-6074.tumimm22-a51

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma

Autor: Iwei Yeh, Hong Wu, Elizabeth P. Murchison, Vivek Iyer, Louise van der Weyden, Courtney R. Schott, Fernando Constantino-Casas, Mark J. Arends, Nancy M. Joseph, Geoffrey A. Wood, Inigo Martincorena, A. K. Foote, Boris C. Bastian, Sionagh Smith, Douglas R. Fullen, Marieke L. Kuijjer, Carla Daniela Robles-Espinoza, Kim Wong, David J. Adams, Thomas Brenn, Jane Dobson, Paul W. Harms, Rajiv M. Patel

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Wong, K, van der Weyden, L, Schott, C R, Foote, A, Constantino-Casas, F, Smith, S, Dobson, J M, Murchison, E P, Wu, H, Yeh, I, Fullen, D R, Joseph, N, Bastian, B, Patel, R M, Martincorena, I, Robles-Espinoza, C D, Iyer, V, Kuijjer, M L, Arends, M J, Brenn, T, Harms, P W, Wood, G A & Adams, D J 2019, ' Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma ', Nature Communications . https://doi.org/10.1038/s41467-018-08081-1
Nature communications, vol 10, iss 1

Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ded87a71d185c8d6be0b0ff1f79c1f
https://doaj.org/article/4e13d3e9fe6547238116ebda7ade7244

An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression

Autor: Brandon Golding, Andrew C. Poon, Geoffrey A. Wood, Benjamin Deheshi, Robert A. Jones, Courtney R. Schott, Anthony J. Mutsaers, Anita K. Luu, Roa’a Hamed, Alicia Viloria-Petit

Publikováno v: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-22 (2018)
BMC Veterinary Research

Background Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression. The role of Hippo signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f70000bd74dad3bf580dd4ca7d6dfd4
http://link.springer.com/article/10.1186/s12917-018-1651-5