Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Courtney R, Plumlee"'
Autor:
Sasha E. Larsen, Hazem F. M. Abdelaal, Courtney R. Plumlee, Sara B. Cohen, Ho D. Kim, Holly W. Barrett, Qingyun Liu, Matthew H. Harband, Bryan J. Berube, Susan L. Baldwin, Sarah M. Fortune, Kevin B. Urdahl, Rhea N. Coler
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The three programs that make up the Immune Mechanisms of Protection Against Mycobacterium tuberculosis Centers (IMPAc-TB) had to prioritize and select strains to be leveraged for this work. The CASCADE team based at Seattle Children’s Research Inst
Externí odkaz:
https://doaj.org/article/aeee2ded1b5d4b998456581f74d8ed36
Autor:
Sara B. Cohen, Courtney R. Plumlee, Lindsay Engels, Dat Mai, Tara A. Murray, Ana N. Jahn, Bridget Alexander, Jared L. Delahaye, Lauren M. Cross, Karolina Maciag, Sam Schrader, Kaitlin Durga, Elizabeth S. Gold, Alan Aderem, Michael Y. Gerner, Benjamin H. Gern, Alan H. Diercks, Kevin B. Urdahl
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
To investigate how host and pathogen diversity govern immunity against Mycobacterium tuberculosis (Mtb), we performed a large-scale screen of vaccine-mediated protection against aerosol Mtb infection using three inbred mouse strains [C57BL/6 (B6), C3
Externí odkaz:
https://doaj.org/article/8f1d5d9be6814725a222414224aa913c
Autor:
Courtney R Plumlee, Holly W Barrett, Danica E Shao, Katie A Lien, Lauren M Cross, Sara B Cohen, Paul T Edlefsen, Kevin B Urdahl
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011825 (2023)
Despite widespread immunization with Bacille-Calmette-Guérin (BCG), the only currently licensed tuberculosis (TB) vaccine, TB remains a leading cause of mortality globally. There are many TB vaccine candidates in the developmental pipeline, but the
Externí odkaz:
https://doaj.org/article/312bbc85b8014851a259ff53ee61ece1
Autor:
Samuel J. Vidal, Daniel Sellers, Jingyou Yu, Shoko Wakabayashi, Jaimie Sixsmith, Malika Aid, Julia Barrett, Sage F. Stevens, Xiaowen Liu, Wenjun Li, Courtney R. Plumlee, Kevin B. Urdahl, Amanda J. Martinot, Dan H. Barouch
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106963- (2023)
Summary: Bacillus Calmette–Guérin (BCG) remains the only approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next-generation TB vaccines typically use a murine aerosol model with a supraphysiologic challenge dose. H
Externí odkaz:
https://doaj.org/article/b3c8b12162af49ab8b180e105b37998b
Autor:
Donald D. Nyangahu, Courtney R. Plumlee, Bryan P. Brown, Colin Feng, Enock Havyarimana, Sara B. Cohen, Kevin B. Urdahl, Heather B. Jaspan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Whether antibiotic treatment during gestation impacts T cell immunity to vaccination in offspring is unexplored. Dams treated with polymyxin B (PMB) during gestation (Mg) displayed altered microbial communities prior to delivery compared to
Externí odkaz:
https://doaj.org/article/c3f90140fb294d4f9423d4d78a810a11
Autor:
Amanda J Martinot, Eryn Blass, Jingyou Yu, Malika Aid, Shant H Mahrokhian, Sara B Cohen, Courtney R Plumlee, Rafael A Larocca, Noman Siddiqi, Shoko Wakabayashi, Michelle Gardner, Rebecca Audette, Anne Devorak, Kevin B Urdahl, Eric J Rubin, Dan H Barouch
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009096 (2020)
Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis
Externí odkaz:
https://doaj.org/article/5618c6f81d13453f82e4f2111c2896a8
Autor:
Johannes Nemeth, Gregory S Olson, Alissa C Rothchild, Ana N Jahn, Dat Mai, Fergal J Duffy, Jared L Delahaye, Sanjay Srivatsan, Courtney R Plumlee, Kevin B Urdahl, Elizabeth S Gold, Alan Aderem, Alan H Diercks
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008655 (2020)
Progress in tuberculosis vaccine development is hampered by an incomplete understanding of the immune mechanisms that protect against infection with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Although the M72/ASOE1 trial y
Externí odkaz:
https://doaj.org/article/8b125e515468469890da614482c96ca1
Autor:
Caleb R. Stoltzfus, Jakub Filipek, Benjamin H. Gern, Brandy E. Olin, Joseph M. Leal, Yajun Wu, Miranda R. Lyons-Cohen, Jessica Y. Huang, Clarissa L. Paz-Stoltzfus, Courtney R. Plumlee, Thomas Pöschinger, Kevin B. Urdahl, Mario Perro, Michael Y. Gerner
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Recently developed approaches for highly multiplexed imaging have revealed complex patterns of cellular positioning and cell-cell interactions with important roles in both cellular- and tissue-level physiology. However, tools to quantitative
Externí odkaz:
https://doaj.org/article/1df5a2d1e3124838b0964fff24a70671
Autor:
Samuel J. Vidal, Daniel Sellers, Jingyou Yu, Shoko Wakabayashi, Jaimie Sixsmith, Malika Aid, Julia Barrett, Sage F. Stevens, Xiaowen Liu, Wenjun Li, Courtney R. Plumlee, Kevin B. Urdahl, Amanda J. Martinot, Dan H. Barouch
Bacillus Calmette–Guérin (BCG) remains the only clinically approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next generation TB vaccines have typically used a murine aerosol challenge model that employs a high sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c49746640785b2b3dec277ce287112
https://doi.org/10.1101/2023.03.17.533226
https://doi.org/10.1101/2023.03.17.533226
Autor:
Shahin Shafiani, Kevin B. Urdahl, Michael Y. Gerner, Benjamin H. Gern, Jared L. Delahaye, Sara B. Cohen, Courtney R. Plumlee
Publikováno v:
The Journal of Immunology. 203:807-812
Growing evidence suggests the outcome of Mycobacterium tuberculosis infection is established rapidly after exposure, but how the current tuberculosis vaccine, bacillus Calmette–Guérin (BCG), impacts early immunity is poorly understood. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e8f607f0213323277850d325abbfc2d
https://doi.org/10.4049/jimmunol.1900108
https://doi.org/10.4049/jimmunol.1900108