Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Courtney Myhr"'
Autor:
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander I. Agoulnik
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Externí odkaz:
https://doaj.org/article/50c86baebeb04e3ebabf87beea0be0a0
Autor:
Maria Esteban‐Lopez, Kenneth Wilson, Courtney Myhr, Elena Kaftanovskaya, Mark Henderson, Noel Southall, Xin Hu, Elena Barnaeva, Marc Ferrer, David Kim, Wenjuan Ye, Roy Morello, Irina Agoulnik, Juan Marugan, Alexander Agoulnik
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ad5c49f8f94318efaa4ff56a2f77683
https://doi.org/10.1096/fasebj.2022.36.s1.r2398
https://doi.org/10.1096/fasebj.2022.36.s1.r2398
Autor:
Elena Barnaeva, Courtney Myhr, Noel Southall, Brian A. Ho, Elena M. Kaftanovskaya, Irina U. Agoulnik, Mariluz Soula, Kenneth Wilson, Hooi Hooi Ng, Thomas Shupe, Marc Ferrer, Juan J. Marugan, Colin E. Bishop, Bryan Rivas, Briana Cervantes, Alexander I. Agoulnik
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f38dc8b82fd316f8eb185572dff28e30
https://doi.org/10.1530/endoabs.63.gp223
https://doi.org/10.1530/endoabs.63.gp223
Autor:
Kenneth Wilson, Noel Southall, Courtney Myhr, Colin E. Bishop, Marc Ferrer, Elena M. Kaftanovskaya, Hooi Hooi Ng, Xin Hu, Juan J. Marugan, Bryan Rivas, Thomas Shupe, Alexander I. Agoulnik, Irina U. Agoulnik
Publikováno v:
Journal of the Endocrine Society
Fibrosis is an underlying cause of cirrhosis and hepatic failure resulting in end stage liver disease with limited pharmacological therapeutic options. The beneficial effects of relaxin peptide treatment have been demonstrated previously in clinicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce12edca459ace95130fe50e98144b69
https://doi.org/10.1210/js.2019-sat-035
https://doi.org/10.1210/js.2019-sat-035
Autor:
Alexander I. Agoulnik, Jingbo Xiao, Juan J. Marugan, Emmett R. George, Zaohua Huang, Irina U. Agoulnik, Courtney Myhr, Noel Southall, Catherine Z. Chen, Marc Ferrer, Xin Xu, Xin Hu, Elena Barnaeva, Kenneth Wilson, Amy Wang, Wei Zheng
Publikováno v:
European journal of medicinal chemistry. 156
A dose responsive quantitative high throughput screen (qHTS) of >350,000 compounds against a human relaxin/insulin-like family peptide receptor (RXFP1) transfected HEK293 cell line identified 2-acetamido-N-phenylbenzamides 1 and 3 with modest agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e586752518d2edf2a88d4833e87067b
https://pubmed.ncbi.nlm.nih.gov/30006176
https://pubmed.ncbi.nlm.nih.gov/30006176
Autor:
Alexander I. Agoulnik, Noel Southall, Zaohua Huang, Irina U. Agoulnik, Juan Marugan, Elena Barnaeva, Courtney Myhr, Brian A. Ho, Jingbo Xiao, Marc Ferrer, Xin Hu, Elena M. Kaftanovskaya, Mariluz Soula
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddaceca66527305c9f9d79d8ed79939c
https://doi.org/10.1530/endoabs.49.ep754
https://doi.org/10.1530/endoabs.49.ep754
Autor:
Zaohua Huang, Irina U. Agoulnik, Alexander I. Agoulnik, Brian A. Ho, Marc Ferrer, Jingbo Xiao, Noel Southall, Amaya Bueno, Xin Hu, Elena Barnaeva, Courtney Myhr, Ross A. D. Bathgate, Juan J. Marugan
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 6 (2015)
Frontiers in Endocrinology, Vol 6 (2015)
Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial. We have identified a small molecule agonist of human RXFP1, ML290; however, it do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40761e94febb3aff67c1da36886cc7f9
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(6)
It is commonly accepted that androgen-producing fetal Leydig cells (FLC) are substituted by adult Leydig cells (ALC) during perinatal testis development. The mechanisms influencing this process are unclear. We used mice with a retinoid acid receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa969d4c186a5b4aafced1c38c27573
https://pubmed.ncbi.nlm.nih.gov/25713029
https://pubmed.ncbi.nlm.nih.gov/25713029