Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Courtney M. Smith"'
Autor:
Joann Chongsaritsinsuk, Alexandra D. Steigmeyer, Keira E. Mahoney, Mia A. Rosenfeld, Taryn M. Lucas, Courtney M. Smith, Alice Li, Deniz Ince, Fiona L. Kearns, Alexandria S. Battison, Marie A. Hollenhorst, D. Judy Shon, Katherine H. Tiemeyer, Victor Attah, Catherine Kwon, Carolyn R. Bertozzi, Michael J. Ferracane, Mark A. Lemmon, Rommie E. Amaro, Stacy A. Malaker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4) decorate immune cells an
Externí odkaz:
https://doaj.org/article/c4f9c600267c4d6cb125292d69f93726
Autor:
Esther R. Berko, Gabriela M. Witek, Smita Matkar, Zaritza O. Petrova, Megan A. Wu, Courtney M. Smith, Alex Daniels, Joshua Kalna, Annie Kennedy, Ivan Gostuski, Colleen Casey, Kateryna Krytska, Mark Gerelus, Dean Pavlick, Susan Ghazarian, Julie R. Park, Araz Marachelian, John M. Maris, Kelly C. Goldsmith, Ravi Radhakrishnan, Mark A. Lemmon, Yaël P. Mossé
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Activating point mutations in Anaplastic Lymphoma Kinase (ALK) have positioned ALK as the only mutated oncogene tractable for targeted therapy in neuroblastoma. Cells with these mutations respond to lorlatinib in pre-clinical studies, provid
Externí odkaz:
https://doaj.org/article/c0e4bcb6136d4cc7a5072df22f3d7275
Publikováno v:
Biochemical Journal
Co-signaling receptors for the T cell receptor (TCR) are important therapeutic targets, with blockade of co-inhibitory receptors such as PD-1 now central in immuno-oncology. Advancing additional therapeutic immune modulation approaches requires under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2502c1212ac9d2a6fd79df79ddcf36e
https://pubmed.ncbi.nlm.nih.gov/34813649
https://pubmed.ncbi.nlm.nih.gov/34813649
SUMMARYCo-signaling receptors for the T cell receptor are important therapeutic targets, with blocking co-inhibitory receptors such as PD-1 now central in immuno-oncology. Advancing additional therapeutic immune modulation approaches requires underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b766629f3fe550e914c05b4a3ce1f7
https://doi.org/10.1101/2021.05.07.443190
https://doi.org/10.1101/2021.05.07.443190
Autor:
Yael P. Mosse, Courtney M. Smith, Krishna Suresh, Ravi Radhakrishnan, Abigail A Lemmon, Keshav Patil, Jin H. Park, Mark A. Lemmon, Earl Joseph Jordan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance High-risk tumors are genomically heterogeneous, harboring gene amplifications and mutations. The activation status of mutated proteins in cancer can profoundly impact disease progression, patient response, and drug sensitivity. Yet, outs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9199b12102cdd0e542ec239a708e35af
http://europepmc.org/articles/PMC7958353
http://europepmc.org/articles/PMC7958353
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immune checkpoint blockade has proven effective in targeting exhausted T-cells to reactivate the immune system against cancer. However, the majority of patients fail to respond to currently available therapies, which primarily target PD-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a097fea1a4dedaea588089859e74321
https://doaj.org/article/2388bde3777f4e8aa2ea2c08efa29cc5
https://doaj.org/article/2388bde3777f4e8aa2ea2c08efa29cc5
Publikováno v:
Cancer Immunology Research. 9:PO032-PO032
Immune responses have been successfully reactivated in cancer by targeting inhibitory receptors such as PD-1 on exhausted T cells to block immune checkpoints. Many patients do not respond, however, and a key challenge in immuno-oncology is to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c711ba09904829ee38f66b96dfbf943
https://doi.org/10.1158/2326-6074.tumimm20-po032
https://doi.org/10.1158/2326-6074.tumimm20-po032
Autor:
Janet DiPiero, Glen B. Banks, Leslie K. Jacobsen, Nino Devidze, Denise Bounous, Linda J. Bristow, Stephen A. Stimpson, Sean C. Little, Michael K. Ahlijanian, Robert C. Gagnon, Courtney M. Smith, Mark J. Majchrzak, Alan S. Robertson, Fizal Nabbie
Publikováno v:
Neuromuscular disorders : NMD. 27(7)
Enzyme-linked and electrochemiluminescence immunoassays were developed for quantification of amino (N-) terminal fragments of the skeletal muscle protein titin (N-ter titin) and qualified for use in detection of urinary N-ter titin excretion. Urine f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dd2f31cd418e94fcc888a18148027a
https://pubmed.ncbi.nlm.nih.gov/28554556
https://pubmed.ncbi.nlm.nih.gov/28554556
Autor:
Courtney M. Smith, A. Coughlan, Mark R. Towler, Sarah P. Hudson, Fathima Laffir, Anthony W. Wren
Publikováno v:
Journal of Biomedical Materials Research Part A. 103:709-720
This study aims to investigate the solubility of a series of titanium (TiO2)-containing bioactive glasses and their subsequent effect on cell viability. Five glasses were synthesized in the composition range SiO2–Na2O–CaO with 5 mol % of incremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14fda35b0689d3399add0304a883dcd
https://doi.org/10.1002/jbm.a.35223
https://doi.org/10.1002/jbm.a.35223
Autor:
Anthony W, Wren, Aisling, Coughlan, Courtney M, Smith, Sarah P, Hudson, Fathima R, Laffir, Mark R, Towler
Publikováno v:
Journal of biomedical materials research. Part A. 103(2)
This study aims to investigate the solubility of a series of titanium (TiO2 )-containing bioactive glasses and their subsequent effect on cell viability. Five glasses were synthesized in the composition range SiO2 -Na2 O-CaO with 5 mol % of increment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7e9bb4826dd681536a08e83bc2d632e
https://pubmed.ncbi.nlm.nih.gov/24825479
https://pubmed.ncbi.nlm.nih.gov/24825479