Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Courtney M. MacMullen"'
Autor:
Brian S. Muntean, Stefano Zucca, Courtney M. MacMullen, Maria T. Dao, Caitlin Johnston, Hideki Iwamoto, Randy D. Blakely, Ronald L. Davis, Kirill A. Martemyanov
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 255-268 (2018)
Summary: Modulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that control the production of second messengers directly im
Externí odkaz:
https://doaj.org/article/207ebaaf212843c9b8f60c16dd36bffd
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209405 (2018)
Cognitive decline is a common occurrence of the natural aging process in animals and studying age-related changes in gene expression in the brain might shed light on disrupted molecular pathways that play a role in this decline. The fruit fly is a us
Externí odkaz:
https://doaj.org/article/c64389d41f274b949d1e7df1637afcb1
Autor:
Courtney M. MacMullen, Ronald L. Davis
Publikováno v:
SLAS Discov
There is a critical need to develop high throughput assays to identify compounds that offer therapy for individuals suffering from neurodegenerative diseases. Most brain disorders, including neurodegenerative diseases, share the common neuropathology
Autor:
Ronald L. Davis, Boglárka H. Várkuti, Miklós Képiró, Kyle Vick, Rodrigo Pacifico, Theodore M. Kamenecka, Yosef Avchalumov, Courtney M. MacMullen, Sathyanarayanan V. Puthanveettil, Ze Liu
Publikováno v:
Science Advances
We have identified small molecules that potentiate aspects of mitochondrial dynamics and function in primary neurons.
Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens f
Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens f
Autor:
Ronald L. Davis, Kirill A. Martemyanov, Jacob A. Berry, Ikuo Masuho, Sophie Himmelreich, Courtney M. MacMullen, Nickolas K. Skamangas
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2074-2081 (2017)
Summary Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by
Publikováno v:
Neuron. 90:1230-1242
Summary Forgetting, one part of the brain's memory management system, provides balance to the encoding and consolidation of new information by removing unused or unwanted memories or by suppressing their expression. Recent studies identified the smal
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209405 (2018)
PLoS ONE
PLoS ONE
Cognitive decline is a common occurrence of the natural aging process in animals and studying age-related changes in gene expression in the brain might shed light on disrupted molecular pathways that play a role in this decline. The fruit fly is a us
Autor:
Ronald L. Davis, Courtney M. MacMullen, Hideki Iwamoto, Randy D. Blakely, Kirill A. Martemyanov, Stefano Zucca, Caitlin Johnston, Brian S. Muntean, Maria T. Dao
Publikováno v:
Cell reports
Cell Reports, Vol 22, Iss 1, Pp 255-268 (2018)
Cell Reports, Vol 22, Iss 1, Pp 255-268 (2018)
Summary: Modulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that control the production of second messengers directly im
Autor:
Jie FANG, Betty Y. L. HSU, Courtney M. MacMULLEN, Mortimer PONCZ, Thomas J. SMITH, Charles A. STANLEY
Publikováno v:
Biochemical Journal. 363:81-87
Glutamate dehydrogenase (GDH) catalyses the reversible oxidative deamination of l-glutamate to 2-oxoglutarate in the mitochondrial matrix. In mammals, this enzyme is highly regulated by allosteric effectors. The major allosteric activator and inhibit
Publikováno v:
Translational Psychiatry
Bipolar disorder is a highly heritable neuropsychiatric disorder affecting nearly 2.5% of the population. Prior genetic studies identified a panel of common and rare single-nucleotide polymorphisms associated with the disease that map to the first in