Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Courtney M. Karner"'
Publikováno v:
Advanced NanoBiomed Research, Vol 4, Iss 3, Pp n/a-n/a (2024)
Natural biomaterials are commonly used as tissue engineering scaffolds due to their biocompatibility and biodegradability. Plant‐derived materials have also gained significant interest due to their abundance and as a sustainable resource. This stud
Externí odkaz:
https://doaj.org/article/715fa09f712e4365a1dc16d4f353f3da
Autor:
Guoli Hu, Yilin Yu, Deepika Sharma, Shondra M. Pruett-Miller, Yinshi Ren, Guo-Fang Zhang, Courtney M. Karner
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Reactive oxygen species (ROS) are natural products of mitochondrial oxidative metabolism and oxidative protein folding. ROS levels must be well controlled, since elevated ROS has been shown to have deleterious effects on osteoblasts. Moreover, excess
Externí odkaz:
https://doaj.org/article/89da8b896fec4947aa6487fc924fff67
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation an
Externí odkaz:
https://doaj.org/article/aafa3112cbdb4c6dbb81c13774be7717
Autor:
Amber T. Collins, Guoli Hu, Hunter Newman, Michael H. Reinsvold, Monique R. Goldsmith, John N. Twomey-Kozak, Holly A. Leddy, Deepika Sharma, Leyao Shen, Louis E. DeFrate, Courtney M. Karner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Osteoarthritis is a debilitating disease characterized by cartilage degradation and altered cartilage mechanical properties. Furthermore, it is well established that obesity is a primary risk factor for osteoarthritis. The purpose of this st
Externí odkaz:
https://doaj.org/article/3a6956c4a3614608acf2c34be56a4605
Autor:
Wendi Guo, Kassandra V. Spiller, Jackie Tang, Courtney M. Karner, Matthew J. Hilton, Colleen Wu
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102317- (2021)
Culture expanded bone marrow stromal cells (BMSCs) are easily isolated, can be grown rapidly en masse, and contain both skeletal stem cells (SSCs) and multipotent mesenchymal progenitors (MMPs). Despite this functional heterogeneity, BMSCs continue t
Externí odkaz:
https://doaj.org/article/ab4998df30f04e229bd151da11861c1e
Publikováno v:
eLife, Vol 11 (2022)
Cellular differentiation is associated with the acquisition of a unique protein signature that is essential to attain the ultimate cellular function and activity of the differentiated cell. This is predicted to result in unique biosynthetic demands t
Externí odkaz:
https://doaj.org/article/edc67b6ea8e5440c940fc0a023481e29
Autor:
Jason T Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M Karner, Matthew J Hilton
Publikováno v:
eLife, Vol 11 (2022)
Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that skeletal stem and progenitor cel
Externí odkaz:
https://doaj.org/article/e5000bdddb6c48f5925edceea43da35c
Publikováno v:
eLife, Vol 10 (2021)
Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production. How osteoblasts obtain or maintain i
Externí odkaz:
https://doaj.org/article/989afff665284dbf82c658c7227d27a9
Autor:
Zhaoyang Liu, Amro A Hussien, Yunjia Wang, Terry Heckmann, Roberto Gonzalez, Courtney M Karner, Jess G Snedeker, Ryan S Gray
Publikováno v:
eLife, Vol 10 (2021)
Adolescent idiopathic scoliosis (AIS) is the most common spine disorder affecting children worldwide, yet little is known about the pathogenesis of this disorder. Here, we demonstrate that genetic regulation of structural components of the axial skel
Externí odkaz:
https://doaj.org/article/0070ed8fe4494e319c06934e1804dbc1
Autor:
Rachel A Johnston, Philippe Vullioud, Jack Thorley, Henry Kirveslahti, Leyao Shen, Sayan Mukherjee, Courtney M Karner, Tim Clutton-Brock, Jenny Tung
Publikováno v:
eLife, Vol 10 (2021)
In some mammals and many social insects, highly cooperative societies are characterized by reproductive division of labor, in which breeders and nonbreeders become behaviorally and morphologically distinct. While differences in behavior and growth be
Externí odkaz:
https://doaj.org/article/ddd2cd5ad0ea49969b42364aa3732086