Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice

Autor: Rosemary M. Clark, Courtney M. Clark, Katherine E.A. Lewis, Marcus S. Dyer, Jyoti A. Chuckowree, Joshua A. Hoyle, Catherine A. Blizzard, Tracey C. Dickson

Publikováno v: Annals of Clinical and Translational Neurology, Vol 10, Iss 11, Pp 1985-1999 (2023)

Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), recent evidence supports

Externí odkaz: https://doaj.org/article/246d624c3fe4468296d9e6f8d246f7ba

Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43A315T Mouse Model of Amyotrophic Lateral Sclerosis

Autor: Emily E. Handley, Laura A. Reale, Jyoti A. Chuckowree, Marcus S. Dyer, Grace L. Barnett, Courtney M. Clark, William Bennett, Tracey C. Dickson, Catherine A. Blizzard

Publikováno v: Molecular Neurobiology. 59:2962-2976

Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex function affected early in disease. Younger females have a lower relative risk of succumbing to ALS than males and older females, implicating a role for female sex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec2b659104244da6797292227d5d5c36
https://doi.org/10.1007/s12035-022-02742-5

Tergal and pleural wing‐related tissues in the German cockroach and their implication to the evolutionary origin of insect wings

Autor: Ana Fernandez-Nicolas, Courtney M. Clark-Hachtel, Yoshinori Tomoyasu, Xavier Bellés

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

This article also appears in: Evolution 2021, Evolution 2021 Virtual Issue.
The acquisition of wings has facilitated the massive evolutionary success of pterygotes (winged insects), which now make up nearly three-quarters of described metazoans.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cffc7bfd181152bd9fe41fd627fce1a
https://doi.org/10.1111/ede.12372

Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis

Autor: Rosemary Clark, Joshua A. Hoyle, Courtney M. Clark, Tracey C. Dickson

Publikováno v: Journal of Neurochemistry. 156:273-289

Neuropeptide Y (NPY) is an endogenous peptide of the central and enteric nervous systems which has gained significant interest as a potential neuroprotective agent for treatment of neurodegenerative disease. Amyotrophic lateral sclerosis (ALS) is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365d006af7904fbf9dbe2da780b23ae0
https://doi.org/10.1111/jnc.15125

Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS

Autor: Catriona McLean, Rosemary Clark, Joshua A. Hoyle, JA Chuckowree, Tracey C. Dickson, Courtney M. Clark

Publikováno v: Brain Sciences, Vol 11, Iss 969, p 969 (2021)
Brain Sciences
Brain Sciences; Volume 11; Issue 8; Pages: 969

Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While GABAergic inputs to upper motor neurons are reduced in models of the disease, less understood is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0c043ea92f0be06575223d7723494a
https://www.mdpi.com/2076-3425/11/8/969