Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Courtney L. Leach"'
1
Akademický článek
Developmental nonlinearity drives phenotypic robustness
Autor: Rebecca M. Green, Jennifer L. Fish, Nathan M. Young, Francis J. Smith, Benjamin Roberts, Katie Dolan, Irene Choi, Courtney L. Leach, Paul Gordon, James M. Cheverud, Charles C. Roseman, Trevor J. Williams, Ralph S. Marcucio, Benedikt Hallgrímsson
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in c
Externí odkaz: https://doaj.org/article/4cead5cb41ca4d3196d3cbf94d5c65c2
Zobrazit plný text záznamu
2
Nonlinear gene expression-phenotype relationships contribute to variation and clefting in the A/WySn mouse
Autor: Rebecca M. Green, Virginia M. Diewert, Courtney L. Leach, Nathan M. Young, Eric J. Schmidt, Ralph S. Marcucio, Jose D Aponte, Charles C. Roseman, Benedikt Hallgrímsson, James M. Cheverud
Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists, vol 248, iss 12
Dev Dyn
Background Cleft lip and palate is one of the most common human birth defects, but the underlying etiology is poorly understood. The A/WySn mouse is a spontaneously occurring model of multigenic clefting in which 20% to 30% of individuals develop an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224d8f7d2f77e9991a3092710a49e4ae
https://escholarship.org/uc/item/2sh2d2bg
Zobrazit plný text záznamu
3
Quantifying three-dimensional morphology and RNA from individual embryos
Autor: Benedikt Hallgrímsson, Ralph S. Marcucio, Rebecca M. Green, Courtney L. Leach, Natasha Hoehn
Publikováno v: Developmental Dynamics. 246:431-436
Quantitative analysis of morphogenesis aids our understanding of developmental processes by providing a method to link changes in shape with cellular and molecular processes. Over the last decade, many methods have been developed for 3D imaging of em
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9ffd20c4b49c37e10b1172611a59336
https://doi.org/10.1002/dvdy.24490
Zobrazit plný text záznamu
6
Developmental nonlinearity drives phenotypic robustness
Autor: Charles C. Roseman, Jennifer L. Fish, Ralph S. Marcucio, Francis J. Smith, Katie Dolan, Benjamin Roberts, Rebecca M. Green, James M. Cheverud, Paul M. K. Gordon, Courtney L. Leach, Irene Choi, Nathan M. Young, Trevor Williams, Benedikt Hallgrímsson
Publikováno v: Nature communications, vol 8, iss 1
Green, RM; Fish, JL; Young, NM; Smith, FJ; Roberts, B; Dolan, K; et al.(2017). Developmental nonlinearity drives phenotypic robustness. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-02037-7. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2dz3w95q
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Robustness to perturbation is a fundamental feature of complex organisms. Mutations are the raw material for evolution, yet robustness to their effects is required for species survival. The mechanisms that produce robustness are poorly understood. No
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecf4b29aa90a453fb8022d59ee0d76f
https://doi.org/10.1038/s41467-017-02037-7
Zobrazit plný text záznamu
8
Akademický článek
Quantifying three-dimensional morphology and RNA from individual embryos.
Autor: Green, Rebecca M., Leach, Courtney L., Hoehn, Natasha, Marcucio, Ralph S., Hallgrímsson, Benedikt
Publikováno v: Developmental Dynamics; May2017, Vol. 246 Issue 5, p431-436, 6p
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje