Výsledky vyhledávání - "Courtney L. Fisher"

Mineralocorticoid receptor antagonism improves transient receptor potential vanilloid 4-dependent dilation of cerebral parenchymal arterioles and cognition in a genetic model of hypertension

Autor: Laura C. Chambers, Janice M. Diaz-Otero, Courtney L. Fisher, William F. Jackson, Anne M. Dorrance

Publikováno v: Journal of Hypertension. 40:1722-1734

In a model of secondary hypertension, mineralocorticoid receptor (MR) antagonism during the development of hypertension prevents the impairment of transient receptor potential vanilloid 4 (TRPV4) activation in parenchymal arterioles (PAs) and cogniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69851da53e362853210a7342f429e4b
https://doi.org/10.1097/hjh.0000000000003208

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Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation

Autor: Courtney L. Fisher, Lucas B. Fallot, Tina C. Wan, Robert F. Keyes, R. Rama Suresh, Amy C. Rothwell, Zhan-Guo Gao, John D. McCorvy, Brian C. Smith, Kenneth A. Jacobson, John A. Auchampach

Publikováno v: ACS Pharmacology & Translational Science. 5:625-641

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a18e1bae71fc0155f4622d56a4848e1
https://doi.org/10.1021/acsptsci.2c00076

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Structure-Activity Studies of 1

Autor: Lucas B, Fallot, R Rama, Suresh, Courtney L, Fisher, Veronica, Salmaso, Robert D, O'Connor, Noy, Kaufman, Zhan-Guo, Gao, John A, Auchampach, Kenneth A, Jacobson

Publikováno v: Journal of medicinal chemistry. 65(22)

We previously reported 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7012c2a311e41895e95c086cfa98e5ea
https://pubmed.ncbi.nlm.nih.gov/36367749

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Characterization of Novel A 3 Adenosine Receptor Allosteric Modulators

Autor: Courtney L. Fisher, Tina C. Wan, Lucas B. Fallot, Robert F. Keyes, R. R. Suresh, Amy C. Rothwell, Zhan‐Guo Gao, John D. McCorvy, Brian C. Smith, Kenneth A. Jacobson, John A. Auchampach

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c0c7d444b58fef0c70e0d60216a85a3
https://doi.org/10.1096/fasebj.2022.36.s1.00r64

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Characterization of Dual-Acting A

Autor: Courtney L, Fisher, Lucas B, Fallot, Tina C, Wan, Robert F, Keyes, R Rama, Suresh, Amy C, Rothwell, Zhan-Guo, Gao, John D, McCorvy, Brian C, Smith, Kenneth A, Jacobson, John A, Auchampach

Publikováno v: ACS pharmacologytranslational science. 5(8)

The A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a24cb6899b1f64487acc17eed0e37ee9
https://pubmed.ncbi.nlm.nih.gov/35983277

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Structure-Activity Studies of 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators

Autor: Lucas B. Fallot, R. Rama Suresh, Courtney L. Fisher, Veronica Salmaso, Robert D. O’Connor, Noy Kaufman, Zhan-Guo Gao, John A. Auchampach, Kenneth A. Jacobson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4803318c3b75de040003732ec1f381c
https://hdl.handle.net/11577/3462482

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Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A

Autor: Dilip K, Tosh, Veronica, Salmaso, Harsha, Rao, Amelia, Bitant, Courtney L, Fisher, David I, Lieberman, Helmut, Vorbrüggen, Marc L, Reitman, Oksana, Gavrilova, Zhan-Guo, Gao, John A, Auchampach, Kenneth A, Jacobson

Publikováno v: J Med Chem

Dopamine-derived N(6)-substituents, compared to N(6)-(2-phenylethyl), in truncated (N)-methanocarba (bicyclo[3.1.0]hexyl) adenosines favored high A(3) adenosine receptor (AR) affinity/selectivity, e.g. C2-phenylethynyl analogue 15 (MRS7591, K(i) 10.9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39ab3dda627bedc9c650d51ef492d63a
https://pubmed.ncbi.nlm.nih.gov/32271569

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Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A3 Adenosine Receptors: Affinity Enhancement by N6-(2-Phenylethyl) Substitution

Autor: Harsha Rao, Helmut Vorbrüggen, Dilip K. Tosh, Oksana Gavrilova, David I. Lieberman, Amelia Bitant, Courtney L. Fisher, Marc L. Reitman, Kenneth A. Jacobson, Veronica Salmaso, John A. Auchampach, Zhan-Guo Gao

Dopamine-derived N6-substituents, compared to N6-(2-phenylethyl), in truncated (N)-methanocarba (bicyclo[3.1.0]hexyl) adenosines favored high A3 adenosine receptor (AR) affinity/selectivity, e.g., ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116156072626387e8dbb0b85c501011b
http://hdl.handle.net/11577/3459811

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Identification and Characterization of ‘Biased’ A 3 Adenosine Receptor Allosteric Modulators

Autor: Amy C. Rothwell, Lucas B. Fallot, John A. Auchampach, Kenneth A. Jacobson, Tina C. Wan, R. Rama Suresh, Amelia Bitant, Zan Guo-Gao, Courtney L. Fisher

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dcdeca7e889d796f6aaf566fa0ecb72
https://doi.org/10.1096/fasebj.2020.34.s1.04488

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