Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Courtney L Jones"'
Autor:
Cristiana O’Brien, Tianyi Ling, Jacob M. Berman, Rachel Culp-Hill, Julie A. Reisz, Vincent Rondeau, Soheil Jahangiri, Jonathan St-Germain, Vinitha Macwan, Audrey Astori, Andy Zeng, Jun Young Hong, Meng Li, Min Yang, Sadhan Jana, Fabia Gamboni, Emily Tsao, Weiyi Liu, John E. Dick, Hening Lin, Ari Melnick, Anastasia Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L. Jones
Publikováno v:
Haematologica, Vol 108, Iss 9 (2023)
Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease-initiating leukemia stem cells (LSC). Previous studies have demonstrated that oxidative phosphorylatio
Externí odkaz:
https://doaj.org/article/365041b041f04292a5cd13ba5d068c3d
Autor:
Rachel Culp-Hill, Brett M. Stevens, Courtney L. Jones, Shanshan Pei, Monika Dzieciatkowska, Mohammad Minhajuddin, Craig T. Jordan, Angelo D’Alessandro
Publikováno v:
Metabolites, Vol 13, Iss 4, p 467 (2023)
Recent advances in targeting leukemic stem cells (LSCs) using venetoclax with azacitidine (ven + aza) has significantly improved outcomes for de novo acute myeloid leukemia (AML) patients. However, patients who relapse after traditional chemotherapy
Externí odkaz:
https://doaj.org/article/65d7f53879dc4307ac50c0ab77af4dac
Autor:
Courtney L. Jones
Publikováno v:
Haematologica, Vol 107, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/5c9c2b8404f640f9ab7a7fa91536b026
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100248- (2021)
Summary: Isolation of leukemia stem cells presents a challenge due to the heterogeneity of the immunophenotypic markers commonly used to identify blood stem cells. Several studies have reported that relative levels of reactive oxygen species (ROS) ca
Externí odkaz:
https://doaj.org/article/b21bac2c3bff4bec873a355d6d5a660b
Autor:
Brett M. Stevens, Nabilah Khan, Angelo D’Alessandro, Travis Nemkov, Amanda Winters, Courtney L. Jones, Wei Zhang, Daniel A. Pollyea, Craig T. Jordan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery an
Externí odkaz:
https://doaj.org/article/7232188cb74f401c89e6e1606e8171e9
Autor:
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Parasvi S. Patel, Fieke W. Hoff, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim P. Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razq Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer
Publikováno v:
Nature Cell Biology, 24(6), 872-884. Nature Publishing Group
Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.M
Autor:
Michael W. Deininger, Thomas O'Hare, Christian A. Olsen, Nima Rajabi, Jamshid S. Khorashad, Siddharth M. Iyer, Hannah M. Redwine, Kevin C. Gantz, James E. Cox, Angelo D'Alessandro, Julie A. Reisz, Christina M. Egbert, Joshua L. Andersen, Shawn C. Owen, William L. Heaton, Phillip M. Clair, Ami B. Patel, Alexandria van Scoyk, Michael J. Xiao, Hein Than, Matthew S. Zabriskie, Courtney L. Jones, Nadeem A. Vellore, Anna V. Senina, Jonathan M. Ahmann, Clinton C. Mason, Orlando Antelope, Brayden J. Halverson, Anthony D. Pomicter, Anca Franzini, Dongqing Yan
The 1,287 genes targeted by the shRNA of the leukemia library.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd5a30d3ac39760b96dc147df3e1e5f
https://doi.org/10.1158/2643-3230.22543690
https://doi.org/10.1158/2643-3230.22543690
Autor:
Michael W. Deininger, Thomas O'Hare, Christian A. Olsen, Nima Rajabi, Jamshid S. Khorashad, Siddharth M. Iyer, Hannah M. Redwine, Kevin C. Gantz, James E. Cox, Angelo D'Alessandro, Julie A. Reisz, Christina M. Egbert, Joshua L. Andersen, Shawn C. Owen, William L. Heaton, Phillip M. Clair, Ami B. Patel, Alexandria van Scoyk, Michael J. Xiao, Hein Than, Matthew S. Zabriskie, Courtney L. Jones, Nadeem A. Vellore, Anna V. Senina, Jonathan M. Ahmann, Clinton C. Mason, Orlando Antelope, Brayden J. Halverson, Anthony D. Pomicter, Anca Franzini, Dongqing Yan
Standard hematologic parameters in SIRT5-/- mice and SIRT5+/+ littermates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2dc73980c351ceea0d9e8bd4c3644c
https://doi.org/10.1158/2643-3230.22543696
https://doi.org/10.1158/2643-3230.22543696
Autor:
Michael W. Deininger, Thomas O'Hare, Christian A. Olsen, Nima Rajabi, Jamshid S. Khorashad, Siddharth M. Iyer, Hannah M. Redwine, Kevin C. Gantz, James E. Cox, Angelo D'Alessandro, Julie A. Reisz, Christina M. Egbert, Joshua L. Andersen, Shawn C. Owen, William L. Heaton, Phillip M. Clair, Ami B. Patel, Alexandria van Scoyk, Michael J. Xiao, Hein Than, Matthew S. Zabriskie, Courtney L. Jones, Nadeem A. Vellore, Anna V. Senina, Jonathan M. Ahmann, Clinton C. Mason, Orlando Antelope, Brayden J. Halverson, Anthony D. Pomicter, Anca Franzini, Dongqing Yan
Plasmids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8a953df11b731912e781dc30644c45
https://doi.org/10.1158/2643-3230.22543681.v1
https://doi.org/10.1158/2643-3230.22543681.v1
Autor:
Michael W. Deininger, Thomas O'Hare, Christian A. Olsen, Nima Rajabi, Jamshid S. Khorashad, Siddharth M. Iyer, Hannah M. Redwine, Kevin C. Gantz, James E. Cox, Angelo D'Alessandro, Julie A. Reisz, Christina M. Egbert, Joshua L. Andersen, Shawn C. Owen, William L. Heaton, Phillip M. Clair, Ami B. Patel, Alexandria van Scoyk, Michael J. Xiao, Hein Than, Matthew S. Zabriskie, Courtney L. Jones, Nadeem A. Vellore, Anna V. Senina, Jonathan M. Ahmann, Clinton C. Mason, Orlando Antelope, Brayden J. Halverson, Anthony D. Pomicter, Anca Franzini, Dongqing Yan
Patient sample information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c2d5d74d26f23bc9beafa8ab7491a6
https://doi.org/10.1158/2643-3230.22543702
https://doi.org/10.1158/2643-3230.22543702