A clinically parameterized mathematical model of Shigella immunity to inform vaccine design.

Autor: Courtney L Davis, Rezwanul Wahid, Franklin R Toapanta, Jakub K Simon, Marcelo B Sztein

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0189571 (2018)

We refine and clinically parameterize a mathematical model of the humoral immune response against Shigella, a diarrheal bacteria that infects 80-165 million people and kills an estimated 600,000 people worldwide each year. Using Latin hypercube sampl

Externí odkaz: https://doaj.org/article/090fd3d1baec42aeabe4e134e4030698

Applying mathematical tools to accelerate vaccine development: modeling Shigella immune dynamics.

Autor: Courtney L Davis, Rezwanul Wahid, Franklin R Toapanta, Jakub K Simon, Marcelo B Sztein, Doron Levy

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e59465 (2013)

We establish a mathematical framework for studying immune interactions with Shigella, a bacteria that kills over one million people worldwide every year. The long-term goal of this novel approach is to inform Shigella vaccine design by elucidating wh

Externí odkaz: https://doaj.org/article/334abb4a9de54999863fe2d718d1fc2c

Peer review perpetuates barriers for historically excluded groups

Autor: Olivia M. Smith, Kayla L. Davis, Riley B. Pizza, Robin Waterman, Kara C. Dobson, Brianna Foster, Julie C. Jarvey, Leonard N. Jones, Wendy Leuenberger, Nan Nourn, Emily E. Conway, Cynthia M. Fiser, Zoe A. Hansen, Ani Hristova, Caitlin Mack, Alyssa N. Saunders, Olivia J. Utley, Moriah L. Young, Courtney L. Davis

Publikováno v: Nature Ecology & Evolution. 7:512-523

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ef085c0130062e033a44100ec743dad
https://doi.org/10.1038/s41559-023-01999-w

Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity

Autor: Beth A. Reinke, Hugo Cayuela, Fredric J. Janzen, Jean-François Lemaître, Jean-Michel Gaillard, A. Michelle Lawing, John B. Iverson, Ditte G. Christiansen, Iñigo Martínez-Solano, Gregorio Sánchez-Montes, Jorge Gutiérrez-Rodríguez, Francis L. Rose, Nicola Nelson, Susan Keall, Alain J. Crivelli, Theodoros Nazirides, Annegret Grimm-Seyfarth, Klaus Henle, Emiliano Mori, Gaëtan Guiller, Rebecca Homan, Anthony Olivier, Erin Muths, Blake R. Hossack, Xavier Bonnet, David S. Pilliod, Marieke Lettink, Tony Whitaker, Benedikt R. Schmidt, Michael G. Gardner, Marc Cheylan, Françoise Poitevin, Ana Golubović, Ljiljana Tomović, Dragan Arsovski, Richard A. Griffiths, Jan W. Arntzen, Jean-Pierre Baron, Jean-François Le Galliard, Thomas Tully, Luca Luiselli, Massimo Capula, Lorenzo Rugiero, Rebecca McCaffery, Lisa A. Eby, Venetia Briggs-Gonzalez, Frank Mazzotti, David Pearson, Brad A. Lambert, David M. Green, Nathalie Jreidini, Claudio Angelini, Graham Pyke, Jean-Marc Thirion, Pierre Joly, Jean-Paul Léna, Anton D. Tucker, Col Limpus, Pauline Priol, Aurélien Besnard, Pauline Bernard, Kristin Stanford, Richard King, Justin Garwood, Jaime Bosch, Franco L. Souza, Jaime Bertoluci, Shirley Famelli, Kurt Grossenbacher, Omar Lenzi, Kathleen Matthews, Sylvain Boitaud, Deanna H. Olson, Tim S. Jessop, Graeme R. Gillespie, Jean Clobert, Murielle Richard, Andrés Valenzuela-Sánchez, Gary M. Fellers, Patrick M. Kleeman, Brian J. Halstead, Evan H. Campbell Grant, Phillip G. Byrne, Thierry Frétey, Bernard Le Garff, Pauline Levionnois, John C. Maerz, Julian Pichenot, Kurtuluş Olgun, Nazan Üzüm, Aziz Avcı, Claude Miaud, Johan Elmberg, Gregory P. Brown, Richard Shine, Nathan F. Bendik, Lisa O’Donnell, Courtney L. Davis, Michael J. Lannoo, Rochelle M. Stiles, Robert M. Cox, Aaron M. Reedy, Daniel A. Warner, Eric Bonnaire, Kristine Grayson, Roberto Ramos-Targarona, Eyup Baskale, David Muñoz, John Measey, F. Andre de Villiers, Will Selman, Victor Ronget, Anne M. Bronikowski, David A. W. Miller

Publikováno v: Science, 376(6600), 1459-1466. American Association for the Advancement of Science (AAAS)
Science
Science, 2022, 376 (6600), pp.1459-1466. ⟨10.1126/science.abm0151⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Comparative studies of mortality in the wild are necessary to understand the evolution of aging; yet, ectothermic tetrapods are underrepresented in this comparative landscape, despite their suitability for testing evolutionary hypotheses. We present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c9e30ddaf8332783e53395f1d0de55
http://hdl.handle.net/1887/3505041

COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes

Autor: Penelope A. Morel, Rosemary A. Aogo, Vivienne Crowe, Amber M. Smith, Morgan Craig, Amanda P. Smith, Xiaoyan Deng, Adrianne L. Jenner, Courtney L. Davis, Sofia Alfonso

Publikováno v: PLoS Pathogens, Vol 17, Iss 7, p e1009753 (2021)

To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results suggest that vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617e46266b1daf77a27ddb325d74e1b3
https://doaj.org/article/86eccbc7e2a545a8b458e4b5aad4d54d