Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Courtney K Walker"'
Autor:
Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial
Externí odkaz:
https://doaj.org/article/4e3a6b68158042169c1a16a3a1c2db46
Autor:
Zhao Sun, Ji-Sun Kwon, Yudong Ren, Shawei Chen, Kitra Cates, Xinguo Lu, Courtney K. Walker, Hande Karahan, Sanja Sviben, James A J Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M. Karch, Randall J. Bateman, Chihiro Sato, Steven J. Mennerick, Marc I. Diamond, Jungsu Kim, Rudolph E. Tanzi, David M. Holtzman, Andrew S. Yoo
Publikováno v:
bioRxiv
Alzheimer’s disease (AD) is a neurodegenerative disorder that primarily affects elderly individuals, and is characterized by hallmark neuronal pathologies including extracellular amyloid-β (Aβ) plaque deposition, intracellular tau tangles, and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440dc641ebbc5e84ef3406eda0d2562f
https://europepmc.org/articles/PMC10245934/
https://europepmc.org/articles/PMC10245934/
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da656d0eca9a744ee007dc34ce245e6a
https://doi.org/10.1002/alz.066840
https://doi.org/10.1002/alz.066840
Autor:
Courtney K Walker, Kelsey M Greathouse, Jennifer J Tuscher, Eric B Dammer, Audrey J Weber, Evan Liu, Kendall A Curtis, Benjamin D Boros, Cameron D Freeman, Jung Vin Seo, Raksha Ramdas, Cheyenne Hurst, Duc M Duong, Marla Gearing, Charles F Murchison, Jeremy J Day, Nicholas T Seyfried, Jeremy H Herskowitz
Publikováno v:
The Journal of Neuroscience. :JN-RM
Proteomic studies utilizing postmortem human brain tissue samples have yielded robust assessments of the aging and neurodegenerative disease(s) proteomes. While these analyses provide lists of molecular alterations in human conditions, like Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7422eed01e309d618f32cf0a54bc7bd
https://doi.org/10.1523/jneurosci.2102-22.2023
https://doi.org/10.1523/jneurosci.2102-22.2023
Autor:
Raksha Ramdas, Emily H. Poovey, Kelsey R. Clearman, Courtney K. Walker, Benjamin D. Boros, Kelsey M. Greathouse, Hamad M. Muhammad, Jeremy H. Herskowitz
Publikováno v:
Neuroscience
Synapse or dendritic spine loss is the strongest correlate of cognitive decline in Alzheimer’s disease (AD), and neurofibrillary tangles (NFTs), but not amyloid-β plaques, associate more closely with transition to mild cognitive impairment. Yet, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7399d1072fcd865cd63523aa79551505
https://doi.org/10.1016/j.neuroscience.2020.12.006
https://doi.org/10.1016/j.neuroscience.2020.12.006
Autor:
Courtney K. Walker, Kelsey M. Greathouse, Evan Liu, Hamad M. Muhammad, Benjamin D. Boros, Cameron D. Freeman, Jung Vin Seo, Jeremy H. Herskowitz
Publikováno v:
Neuroscience. 498
Dendritic spines are small protrusions on dendrites that serve as the postsynaptic site of the majority of excitatory synapses. These structures are important for normal synaptic transmission, and alterations in their density and morphology have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc456b374ae7a867a18bfd6615a53623
https://pubmed.ncbi.nlm.nih.gov/35752428
https://pubmed.ncbi.nlm.nih.gov/35752428
Publikováno v:
Neuroscientist
Cognitive resilience is often defined as the ability to remain cognitively normal in the face of insults to the brain. These insults can include disease pathology, such as plaques and tangles associated with Alzheimer’s disease, stroke, traumatic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9388b038d4afc3f0a467f34ebcc31d
https://europepmc.org/articles/PMC8130863/
https://europepmc.org/articles/PMC8130863/
Autor:
Svitlana V. Bach, Tejeshwar C. Rao, Raksha Ramdas, Courtney K. Walker, Kelsey M. Greathouse, Kendall A. Curtis, Jeremy H. Herskowitz, Jeremy J. Day, Alexa L. Mattheyses, Benjamin W. Henderson
Publikováno v:
Science Signaling. 12
Alzheimer’s disease (AD) therapies predominantly focus on amyloid-β (Aβ), but Aβ effects may be maximal before clinical symptoms appear. Downstream of Aβ, dendritic spine loss correlates most strongly with cognitive decline in AD. Rho-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdee5dee45f6507fa38af239f61d128
https://doi.org/10.1126/scisignal.aaw9318
https://doi.org/10.1126/scisignal.aaw9318
P3-211: PHARMACOLOGIC INHIBITION OF LIM KINASE PROVIDES DENDRITIC SPINE RESILIENCE AGAINST AMYLOID-β
Autor:
Svitlana V. Bach, Nicholas T. Seyfried, Jeremy H. Herskowitz, Jeremy J. Day, Courtney K. Walker, Benjamin W. Henderson, Kelsey M. Greathouse
Publikováno v:
Alzheimer's & Dementia. 15:P1010-P1011
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d81a940c05da84d93df8cc4f100912
https://doi.org/10.1016/j.jalz.2019.06.3241
https://doi.org/10.1016/j.jalz.2019.06.3241
Publikováno v:
Schizophrenia Bulletin. 41:1123-1132
The cause of schizophrenia (SZ) is unknown and no single region of the brain can be pinpointed as an area of primary pathology. Rather, SZ results from dysfunction of multiple neurotransmitter systems and miswiring between brain regions. It is necess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e78cc40de24620b9502c1d83acfcdfe
https://doi.org/10.1093/schbul/sbv030
https://doi.org/10.1093/schbul/sbv030