Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Courtney J. Mycroft‐West"'
Autor:
Courtney J. Mycroft-West, Sahar Abdelkarim, Helen M. E. Duyvesteyn, Neha S. Gandhi, Mark A. Skidmore, Raymond J. Owens, Liang Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix, which are involved in myriad structural and signaling processes. Mature HS polysaccharides contain complex, non-templated patterns of sulfation and epim
Externí odkaz:
https://doaj.org/article/8d75494486084852a741a389473a8453
Autor:
Zachariah P. Schuurs, Edward Hammond, Stefano Elli, Timothy R. Rudd, Courtney J. Mycroft-West, Marcelo A. Lima, Mark A. Skidmore, Richard Karlsson, Yen-Hsi Chen, Ieva Bagdonaite, Zhang Yang, Yassir A. Ahmed, Derek J. Richard, Jeremy Turnbull, Vito Ferro, Deirdre R. Coombe, Neha S. Gandhi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2806-2818 (2021)
SARS-CoV-2 has rapidly spread throughout the world’s population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiotensin-converting enzyme-2
Externí odkaz:
https://doaj.org/article/a6e1525cac0a4242ade18498d4c8849d
Autor:
Scott P. Davies, Courtney J. Mycroft-West, Isabel Pagani, Harriet J. Hill, Yen-Hsi Chen, Richard Karlsson, Ieva Bagdonaite, Scott E. Guimond, Zania Stamataki, Marcelo Andrade De Lima, Jeremy E. Turnbull, Zhang Yang, Elisa Vicenzi, Mark A. Skidmore, Farhat L. Khanim, Alan Richardson
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the di
Externí odkaz:
https://doaj.org/article/1ca1ccf941184afc912bd210a2089c17
Autor:
Courtney J. Mycroft-West, Anthony J. Devlin, Lynsay C. Cooper, Scott E. Guimond, Patricia Procter, Marco Guerrini, Gavin J. Miller, David G. Fernig, Edwin A. Yates, Marcelo A. Lima, Mark A. Skidmore
Publikováno v:
Marine Drugs, Vol 19, Iss 4, p 203 (2021)
Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The widely used clinical anticoagulant heparin has been reported to exert beneficial effects
Externí odkaz:
https://doaj.org/article/9cb423e1e6474f8a8ed5966155f70135
Autor:
James G. Hyatt, Sylvain Prévost, Juliette M. Devos, Courtney J. Mycroft-West, Mark A. Skidmore, Anja Winter
Publikováno v:
Pathogens, Vol 9, Iss 11, p 935 (2020)
Dengue fever is a rapidly emerging vector-borne viral disease with a growing global burden of approximately 390 million new infections per annum. The Dengue virus (DENV) is a flavivirus spread by female mosquitos of the aedes genus, but the mechanism
Externí odkaz:
https://doaj.org/article/a42f050bf8c24cd7a6c2ff5cb207eee9
Autor:
Courtney J. Mycroft-West, Lynsay C. Cooper, Anthony J. Devlin, Patricia Procter, Scott E. Guimond, Marco Guerrini, David G. Fernig, Marcelo A. Lima, Edwin A. Yates, Mark A. Skidmore
Publikováno v:
Marine Drugs, Vol 17, Iss 5, p 293 (2019)
Therapeutic options for Alzheimer’s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzhe
Externí odkaz:
https://doaj.org/article/9b0212c58018467d8dc0b138c8469987
Autor:
Courtney J Mycroft-West, Anthony J Devlin, Lynsay C Cooper, Patricia Procter, Gavin J Miller, David G Fernig, Marco Guerrini, Scott E Guimond, Marcelo A Lima, Edwin A Yates, Mark Andrew Skidmore
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 8, Pp 1546-1553 (2020)
The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target, the primary neuronal β-secretase, β-site
Externí odkaz:
https://doaj.org/article/d30637bf9c56424598842f9e806a405d
Autor:
Michela Parafioriti, Minghong Ni, Maurice Petitou, Courtney J. Mycroft‐West, Timothy R. Rudd, Neha S. Gandhi, Vito Ferro, Jeremy E. Turnbull, Marcelo A. Lima, Mark A. Skidmore, David G. Fernig, Edwin A. Yates, Antonella Bisio, Marco Guerrini, Stefano Elli
Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a conformational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d81f8998e050b337be40018a7c20d2
https://doi.org/10.26434/chemrxiv-2022-21brb-v2
https://doi.org/10.26434/chemrxiv-2022-21brb-v2
Autor:
Courtney J. Mycroft-West, Anthony J. Devlin, Lynsay C. Cooper, Scott E. Guimond, Patricia Procter, Gavin J. Miller, Marco Guerrini, David G. Fernig, Edwin A. Yates, Marcelo A. Lima, Mark A. Skidmore
Publikováno v:
Carbohydrate Research. 525:108747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0216a0e18ffecd2c10c66bcb46ce2472
https://doi.org/10.1016/j.carres.2023.108747
https://doi.org/10.1016/j.carres.2023.108747
Autor:
Yen-Hsi Chen, Richard Karlsson, Timothy R. Rudd, Neha S. Gandhi, Stefano Elli, Mark A. Skidmore, Zhang Yang, Vito Ferro, Marcelo A. Lima, Jeremy E. Turnbull, Derek J. Richard, Deirdre R. Coombe, Courtney J. Mycroft-West, Ieva Bagdonaite, Zachariah P Schuurs, Edward Hammond, Yassir A. Ahmed
Publikováno v:
Schuurs, Z P, Hammond, E, Elli, S, Rudd, T R, Mycroft-West, C J, Lima, M A, Skidmore, M A, Karlsson, R, Chen, Y-H, Bagdonaite, I, Yang, Z, Ahmed, Y A, Richard, D J, Turnbull, J, Ferro, V, Coombe, D R & Gandhi, N S 2021, ' Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain ', Computational and Structural Biotechnology Journal, vol. 19, pp. 2806-2818 . https://doi.org/10.1016/j.csbj.2021.05.002
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2806-2818 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2806-2818 (2021)
Graphical abstract
SARS-CoV-2 has rapidly spread throughout the world’s population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiote
SARS-CoV-2 has rapidly spread throughout the world’s population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1001e268f194e4cdd70b28279a910675
https://doi.org/10.1016/j.csbj.2021.05.002
https://doi.org/10.1016/j.csbj.2021.05.002