Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Courtney J Smith"'
Autor:
Courtney J Smith, Nasa Sinnott-Armstrong, Anna Cichońska, Heli Julkunen, Eric B Fauman, Peter Würtz, Jonathan K Pritchard
Publikováno v:
eLife, Vol 11 (2022)
Pleiotropy and genetic correlation are widespread features in genome-wide association studies (GWAS), but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino aci
Externí odkaz:
https://doaj.org/article/93c24e8d6a9e4e24a0498f5ad88bc407
Autor:
Courtney J. Smith, Les Dethlefsen, Christopher Gardner, Linda Nguyen, Marcus Feldman, Elizabeth K. Costello, Oren Kolodny, David A. Relman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT An outstanding question regarding the human gut microbiota is whether and how microbiota-directed interventions influence host phenotypic traits. Here, we employed a dietary intervention to probe this question in the context of lactose intol
Externí odkaz:
https://doaj.org/article/1511bb5f51084f1a88a38d426d2757f0
Autor:
Roshni A. Patel, Shaila A. Musharoff, Jeffrey P. Spence, Harold Pimentel, Catherine Tcheandjieu, Hakhamanesh Mostafavi, Nasa Sinnott-Armstrong, Shoa L. Clarke, Courtney J. Smith, Peter P. Durda, Kent D. Taylor, Russell Tracy, Yongmei Liu, W. Craig Johnson, Francois Aguet, Kristin G. Ardlie, Stacey Gabriel, Josh Smith, Deborah A. Nickerson, Stephen S. Rich, Jerome I. Rotter, Philip S. Tsao, Themistocles L. Assimes, Jonathan K. Pritchard
Publikováno v:
Am J Hum Genet
Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has
Publikováno v:
Journal of Pediatric Urology.
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of significant hits. However, at present we lack a principled way of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35dac39dd4c125263fb7dc4a68abd6e1
https://doi.org/10.1101/2022.10.04.509926
https://doi.org/10.1101/2022.10.04.509926
Autor:
Yesenia L. Soto, Courtney J. Smith, Emily L. Divino, Deena Kishawi, Jessica H. Kittle, Jessica L. Pierce, Solomiya Logvinenko, Mikaela Donovan, Sebastian A. Slazyk, Mike D. Dotson, Bryan M. McClarty, Gregory B. Kharas
Publikováno v:
Journal of Macromolecular Science, Part A. 54:1-5
Novel trisubstituted ethylenes, ring-disubstituted propyl 2-cyano-3-phenyl-2-propenoates, RPhCH˭C(CN)CO2C3H7 (where R is 2-fluoro-5-methoxy, 2-fluoro-6-methoxy, 3-fluoro-4-methoxy, 4-fluoro-3-methoxy, 5-fluoro-2-methoxy, 2-fluoro-6-methyl, 3-fluoro-
Publikováno v:
Diabetes. 68
The orphan nuclear hormone receptor Nr4a1 plays a critical role in maintaining and expanding functional beta cell mass. Overexpression of Nr4a1 is sufficient to induce beta cell proliferation in primary beta cells by upregulating cell cycle progressi
Autor:
Courtney J. Smith, Jeffery S. Tessem, Kyle B. Kener, Adam G. Wynn, Matthew C. Austin, Jacob A. Herring
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Diabetes. 67
We have shown that the orphan nuclear receptors Nr4a1 and Nr4a3 are critical for beta cell mitochondrial respiration and fuel utilization, and that loss of either factor impedes fuel utilization and insulin secretion. We have also demonstrated that p