Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Courtney Cullis"'
Autor:
Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani
Publikováno v:
Journal of Medicinal Chemistry. 64:6902-6923
Stimulator of Interferon Genes (STING) plays an important role in innate immunity by inducing type I interferon production upon infection with intracellular pathogens. STING activation can promote increased T-cell activation and inflammation in the t
Autor:
Virendar K. Kaushik, Prakash Raman, Ying Sun, Courtney Cullis, Ruth E. Gimeno, Effie Tozzo, Dong Yu Sun, Praveen Sanchetti, Hui Wu, Bing Guan, Tracy J. Jenkins, Peter J. Tummino, Thomas Daniels, Sandhya Punreddy, James Brown, Yingchun Ye, Christopher Blackburn, Stephen M. Condon, Brian K. Hubbard, Stephane Peluso, Suresh K. Balani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3504-3509
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group
Autor:
Christine A. Collins, Victoria Knourek-Segel, Philip R. Kym, Dariusz Wodka, Hing L. Sham, Brad J. Geddes, Rajesh R. Iyengar, Anil Vasudevan, Ju Gao, Su Jen Lai, Elizabeth K. Govek, Thomas A. Fey, Freeman Jennifer C, Gang Zhao, Dennis G Fry, Michael E. Brune, Jennifer Lee Che, Brian D. Dayton, Doug H. Falls, Kennan C. Marsh, Andrew J. Souers, James Brown, Jon Roses, Michael A. Patane, Matthew J. LaMarche, Cathleen Mcdowell, Lee C. Preusser, Lisa E. Hernandez, Mathew M. Mulhern, Courtney Cullis, Tom Marsilje, Sevan Brodjian, Lynch John K, Eugene N. Bush, Sells Todd B, Robin Shapiro, Christopher Blackburn, Andrew S. Judd, Glenn A. Reinhart
Publikováno v:
Journal of Medicinal Chemistry. 48:5888-5891
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further e
Autor:
Hua Liao, Elizabeth Carideo-Cunniff, Erik Koenig, Jingya Ma, Vihren Kolev, John Bradley, James Garnsey, Benjamin S. Amidon, Dongyun Wu, Courtney Cullis, Pooja Shah, Christopher Tsu
Publikováno v:
Cancer Research. 77:1493-1493
Proper mitochondrial function is critical for energy production and the cycling of metabolites required for tumor establishment and growth. LonP1 is an ATP-dependent serine protease that is critical for maintaining mitochondrial protein homeostasis b
Autor:
Matthew O. Duffey, Tricia J. Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Cynthia Barrett, Indu Bharathan, Douglas Bowman, Nancy J. Bump, Ryan Chau, Courtney Cullis, Denise L. Driscoll, Amy Elder, Nancy Forsyth, Jonathan Frazer, Jianping Guo, Luyi Guo, Marc L. Hyer, David Janowick, Bheemashankar Kulkarni, Su-Jen Lai, Kerri Lasky, Gang Li, Jing Li, Debra Liao, Jeremy Little, Bo Peng, Mark G. Qian, Dominic J. Reynolds, Mansoureh Rezaei, Margaret Porter Scott, Todd B. Sells, Vaishali Shinde, Qiuju Judy Shi, Michael D. Sintchak, Francois Soucy, Kevin T. Sprott, Stephen G. Stroud, Michelle Nestor, Irache Visiers, Gabriel Weatherhead, Yingchun Ye, Natalie D’Amore
Publikováno v:
Journal of medicinal chemistry. 55(1)
This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pha
Autor:
Anne L. Burkhardt, Michael Milhollen, Xiaofeng Yang, Huay-Keng Loke, Lawrence R. Dick, Teresa A. Soucy, Irache Visiers, Frank J. Bruzzese, Michael D. Sintchak, James J. Spelman, Steven P. Langston, Ping Li, Kristin B. Hamman, James M. Gavin, Joseph B. Bolen, Nancy Bump, Sells Todd B, Jingya Ma, Christopher F. Claiborne, Stepan Vyskocil, Courtney Cullis, Hua Liao, Mark Rolfe, Dongyun Wu, James E. Brownell, Trupti Lingaraj, William D. Mallender
Publikováno v:
Molecular cell. 37(1)
The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical trials for the treatment of cancer. Here, we show that MLN4924 is a