Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Courtney Coker"'
Autor:
Yifan Tai, Angela Chow, Seoyoung Han, Courtney Coker, Wanchao Ma, Yifan Gu, Valeria Estrada Navarro, Manoj Kandpal, Hanina Hibshoosh, Kevin Kalinsky, Katia Manova-Todorova, Anton Safonov, Elaine M Walsh, Mark Robson, Larry Norton, Richard Baer, Taha Merghoub, Anup K Biswas, Swarnali Acharyya
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1957-1980 (2024)
Abstract Acquired resistance to PARP inhibitors (PARPi) remains a treatment challenge for BRCA1/2-mutant breast cancer that drastically shortens patient survival. Although several resistance mechanisms have been identified, none have been successfull
Externí odkaz:
https://doaj.org/article/2b7acab7d8864163a88c5615d51c25ce
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Autor:
Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin R. M. Lannagan, Tongtong Wang, Josephine A. Wright, Hiroki Kobayashi, Jia Q. Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L. Worthley, Susan L. Woods, Tal Danino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Niss
Externí odkaz:
https://doaj.org/article/16a3783ebc994816bc3440bb05df9c6f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Synthetic biology enables the engineering of bacteria to safely deliver potent payloads to tumors for effective anti-cancer therapies. However, a central challenge for translation is determining ideal bacterial therapy candidates for specifi
Externí odkaz:
https://doaj.org/article/1ea02c3efcf74f9cb07bea2d420aef0a
Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas
Autor:
Paul K. Paik, Jia Luo, Ni Ai, Rachel Kim, Linda Ahn, Anup Biswas, Courtney Coker, Wanchao Ma, Phillip Wong, Darren J. Buonocore, W. Victoria Lai, Jamie E. Chaft, Swarnali Acharyya, Joan Massagué, Mark G. Kris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Generation of TNF-α in response to chemotherapy has been associated with chemo-resistance and metastasis propagation. Here the authors show that the combination of an anti-TNF antibody and cisplatin doublet chemotherapy increases anti-tumor efficacy
Externí odkaz:
https://doaj.org/article/03426524a16147d1b39e9e33d5c9e351
Autor:
Ahmad Rushdi Shakri, Timothy James Zhong, Wanchao Ma, Courtney Coker, Rohaan Hegde, Hanna Scholze, Vanessa Chin, Matthias Szabolcs, Hanina Hibshoosh, Kurenai Tanji, Richard Baer, Anup Kumar Biswas, Swarnali Acharyya
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6766-6775 (2020)
Abstract Nearly 80% of advanced cancer patients are afflicted with cachexia, a debilitating syndrome characterized by extensive loss of muscle mass and function. Cachectic cancer patients have a reduced tolerance to antineoplastic therapies and often
Externí odkaz:
https://doaj.org/article/21f364a05f8948c6935977c5eace599f
Autor:
Nikita Consul, Xiaotao Guo, Courtney Coker, Sara Lopez-Pintado, Hanina Hibshoosh, Binsheng Zhao, Kevin Kalinsky, Swarnali Acharyya
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 2016, Iss 10, Pp 83-94 (2016)
Externí odkaz:
https://doaj.org/article/5843728f5aaa4ac49d2ce5fe11d35533
Autor:
Candice R. Gurbatri, Georgette Radford, Laura Vrbanac, Courtney Coker, Jong-won Im, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin RM Lannagan, Tongtong Wang, Josephine A Wright, Elaine Thomas, Hiroki Kobayashi, Jia Q Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L Worthley, Susan L Woods, Tal Danino
Publikováno v:
bioRxiv
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa60062672f0b39d77dd9740b766a751
https://europepmc.org/articles/PMC10104002/
https://europepmc.org/articles/PMC10104002/
Autor:
Swarnali Acharyya, Joan Massague, Mark G. Kris, Catherine A. Shu, Anjali Saqi, Paul K. Paik, Helena A. Yu, Peter Canoll, Cathy Mendelsohn, Adolfo A. Ferrando, Elisa de Stanchina, Katia Manova-Todorova, Angeliki Mela, Galina G. Lagos, Hanna Scholze, Timothy James Zhong, Ahmad Rushdi Shakri, S. Aidan Quinn, Courtney Coker, Wanchao Ma, Yifan Tai, Seoyoung Han, Anup Kumar Biswas
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib has significantly prolonged progression-free survival (PFS) in patients with EGFR-mutant lung cancer, including those with brain metastases. However, despite stri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2128f27d6b29e788dfb177d8885300b7
https://doi.org/10.1158/2159-8290.c.6549641.v1
https://doi.org/10.1158/2159-8290.c.6549641.v1
Autor:
Swarnali Acharyya, Joan Massague, Mark G. Kris, Catherine A. Shu, Anjali Saqi, Paul K. Paik, Helena A. Yu, Peter Canoll, Cathy Mendelsohn, Adolfo A. Ferrando, Elisa de Stanchina, Katia Manova-Todorova, Angeliki Mela, Galina G. Lagos, Hanna Scholze, Timothy James Zhong, Ahmad Rushdi Shakri, S. Aidan Quinn, Courtney Coker, Wanchao Ma, Yifan Tai, Seoyoung Han, Anup Kumar Biswas
Supplementary Figure from Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ec8e1cd04ff0415b81b32dfa36185
https://doi.org/10.1158/2159-8290.22541435
https://doi.org/10.1158/2159-8290.22541435
Autor:
Thomas M. Savage, Rosa L. Vincent, Sarah S. Rae, Lei Haley Huang, Alexander Ahn, Kelly Pu, Fangda Li, Kenia de los Santos-Alexis, Courtney Coker, Tal Danino, Nicholas Arpaia
Publikováno v:
Science Advances. 9
Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor immunity. Strategies to overcome these exclusion signals remain limited due to an inability to target therapeutics specifically to the tumor. Synthetic biology enab