Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Courtney C, Aldrich"'
Autor:
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich, Dirk Schnappinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic pathway is not fully understood. Here, we show that rv1590, a gene
Externí odkaz:
https://doaj.org/article/3054e679f3564df091570ea68d735626
Autor:
Osha Roopnarine, Samantha L. Yuen, Andrew R. Thompson, Lauren N. Roelike, Robyn T. Rebbeck, Philip A. Bidwell, Courtney C. Aldrich, Razvan L. Cornea, David D. Thomas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract We have used FRET-based biosensors in live cells, in a robust high-throughput screening (HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac sarco/endoplasmic reticulum calcium ATPase (SERCA2a). Ou
Externí odkaz:
https://doaj.org/article/d60af476a07b46be82725dcf9dbef5bf
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT The clinical utility of rifamycins against non-tuberculous mycobacterial (NTM) disease is limited by intrinsic drug resistance achieved by ADP-ribosyltransferase Arr. By blocking the site of ribosylation, we recently optimized a series of an
Externí odkaz:
https://doaj.org/article/8768a64104ff4db583f03e0ec12b9d1c
Autor:
Ritu Sharma, Travis E. Hartman, Tiago Beites, Jee-Hyun Kim, Hyungjin Eoh, Curtis A. Engelhart, Linnan Zhu, Daniel J. Wilson, Courtney C. Aldrich, Sabine Ehrt, Kyu Young Rhee, Dirk Schnappinger
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegen
Externí odkaz:
https://doaj.org/article/58351c1678134138a2c61182375d718c
Autor:
Philip A. Bidwell, Samantha L. Yuen, Ji Li, Kaja Berg, Robyn T. Rebbeck, Courtney C. Aldrich, Osha Roopnarine, Razvan L. Cornea, David D. Thomas
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1789 (2022)
The sarco/endoplasmic reticulum Ca-ATPase (SERCA) is a P-type ion pump that transports Ca2+ from the cytosol into the endoplasmic/sarcoplasmic reticulum (ER/SR) in most mammalian cells. It is critically important in muscle, facilitating relaxation an
Externí odkaz:
https://doaj.org/article/47192f46bcf14156bb18b504fe0cd0a8
Autor:
Cynthia J. Burrows, Jiaxiang Huang, Shu Wang, Hyun Jae Kim, Gerald J. Meyer, Kirk Schanze, T. Randall Lee, Jodie L. Lutkenhaus, David Kaplan, Christopher Jones, Carolyn Bertozzi, Laura Kiessling, Mary Beth Mulcahy, Craig W. Lindsley, M. G. Finn, Joel D. Blum, Prashant Kamat, Wonyong Choi, Shane Snyder, Courtney C. Aldrich, Stuart Rowan, Bin Liu, Dennis Liotta, Paul S. Weiss, Deqing Zhang, Krishna N. Ganesh, Harry A. Atwater, J. Justin Gooding, David T. Allen, Christopher A. Voigt, Jonathan Sweedler, Alanna Schepartz, Vincent Rotello, Sébastien Lecommandoux, Shana J. Sturla, Sharon Hammes-Schiffer, Jillian Buriak, Jonathan W. Steed, Hongwei Wu, Julie Zimmerman, Bryan Brooks, Phillip Savage, William Tolman, Thomas F. Hofmann, Joan F. Brennecke, Thomas A. Holme, Kenneth M. Merz, Gustavo Scuseria, William Jorgensen, Gunda I. Georg, Shaomeng Wang, Philip Proteau, John R. Yates, Peter Stang, Gilbert C. Walker, Marc Hillmyer, Lynne S. Taylor, Teri W. Odom, Erick Carreira, Kai Rossen, Paul Chirik, Scott J. Miller, Joan-Emma Shea, Anne McCoy, Martin Zanni, Gregory Hartland, Gregory Scholes, Joseph A. Loo, James Milne, Sarah B. Tegen, Daniel T. Kulp, Julia Laskin
Publikováno v:
ACS Central Science, Vol 6, Iss 7, Pp 1012-1014 (2020)
Externí odkaz:
https://doaj.org/article/32ff0821badd47688547f16b57e8c9a3
Publikováno v:
The Journal of Organic Chemistry. 88:6209-6217
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb009ed422ca784dfe5a965558dc2826
https://doi.org/10.1021/acs.joc.3c00239
https://doi.org/10.1021/acs.joc.3c00239
Publikováno v:
Molecules, Vol 27, Iss 9, p 2616 (2022)
Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect that is not ea
Externí odkaz:
https://doaj.org/article/1a2444eb7bdc4af7be878de1d143d5d1
Publikováno v:
Expert Opinion on Drug Discovery. 18:363-370
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b408b1a5999a0e960e4453def1a08229
https://doi.org/10.1080/17460441.2023.2178413
https://doi.org/10.1080/17460441.2023.2178413
Autor:
Sachin Sharma, Yahani P. Jayasinghe, Neeraj Kumar Mishra, Moyosore O. Orimoloye, Tsung-Yun Wong, Joseph J. Dalluge, Donald R. Ronning, Courtney C. Aldrich
Publikováno v:
ACS Infectious Diseases. 9:540-553
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1833e1155d3042ee1cb1d7cc459ab3de
https://doi.org/10.1021/acsinfecdis.2c00541
https://doi.org/10.1021/acsinfecdis.2c00541