Single cell and TCR analysis of immune cells from AAV gene therapy-dosed Duchenne muscular dystrophy patients

Autor: Michael R. Emami, Mark A. Brimble, Alejandro Espinoza, Jane Owens, Laurence O. Whiteley, Sandra Casinghino, Thomas A. Lanz, Philip K. Farahat, Matteo Pellegrini, Courtney S. Young, Paul G. Thomas, Elizabeth M. McNally, S. Armando Villalta, Stefan A. Schattgen, Melissa J. Spencer

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101349- (2024)

Clinical trials for Duchenne muscular dystrophy (DMD) are assessing the therapeutic efficacy of systemically delivered adeno-associated virus (AAV) carrying a modified DMD transgene. High vector doses (>1E14 vg/kg) are needed to globally transduce sk

Externí odkaz: https://doaj.org/article/fee20f3ef621479e9e7090e49aade946

An inclusive Research and Education Community (iREC) model to facilitate undergraduate science education reform

Autor: Denise L. Monti, Julia C. Gill, Tamarah L. Adair, Sandra D. Adams, Yesmi Patricia Ahumada-Santos, Isabel Amaya, Kirk Anders, Justin R. Anderson, Mauricio S. Antunes, Mary Ayuk, Frederick Baliraine, Tonya C. Bates, Andrea R. Beyer, Suparna Bhalla, Tejas Bouklas, Sharon K. Bullock, Kristen A. Butela, Christine Byrum, Steven M. Caruso, Rebecca Chong, Hui-Min Chung, Stephanie B. Conant, Brett Condon, Katie E. Crump, Tom D'Elia, Megan K. Dennis, Linda C. DeVeaux, Lautaro Diacovich, Arturo Diaz, Iain Duffy, Dustin Edwards, Patricia C. Fallest-Strobl, Ann Findley, Matthew R. Fisher, Marie P. Fogarty, Victoria Jane Frost, Maria D. Gainey, Courtney S. Galle, Bryan Gibb, Urszula Golebiewska, Hugo Gramajo, Anna S. Grinath, Jennifer Guerrero, Nancy Guild, Kathryn E. Gunn, Susan Gurney, Lee E. Hughes, Pradeepa Jayachandran, Kristen Johnson, Allison Johnson, Alison E. Kanak, Michelle L. Kanther, Rodney A. King, Kathryn Kohl, Julia Lee-Soety, Lynn O. Lewis, Heather Lindberg, Jaclyn A. Madden, Breonna J. Martin, Matthew D. Mastropaolo, Sean McClory, Evan C. Merkhofer, Julie A. Merkle, Jon Mitchell, María Alejandra Mussi, Fernando Nieto, Jillian Nissen, Imade Yolanda Nsa, Mary G. O'Donnell, R. Deborah Overath, Shallee T. Page, Andrea Panagakis, Jesús Ricardo Parra Unda, Michelle B. Pass, Tiara Perez Morales, Nick T. Peters, Ruth Plymale, Richard Pollenz, Nathan S. Reyna, Claire A. Rinehart, Jessica Rocheleau, John S. Rombold, Ombeline Rossier, Adam D. Rudner, Elizabeth E. Rueschhoff, Christopher D. Shaffer, Mary Ann V. Smith, Amy B. Sprenkle, C. Nicole Sunnen, Michael A. Thomas, Michelle M. Tigges, Deborah Tobiason, Sara Sybesma Tolsma, Julie Torruellas Garcia, Peter Uetz, Edwin Vazquez, Catherine M. Ward, Vassie C. Ware, Jacqueline M. Washington, Matthew J. Waterman, Daniel E. Westholm, Keith A. Wheaton, Simon J. White, Elizabeth C. Williams, Daniel C. Williams, Ellen M. Wisner, William H. Biederman, Steven G. Cresawn, Danielle M. Heller, Deborah Jacobs-Sera, Daniel A. Russell, Graham F. Hatfull, David J. Asai, David I. Hanauer, Mark J. Graham, Viknesh Sivanathan

Publikováno v: Frontiers in Education, Vol 9 (2024)

Over the last two decades, there have been numerous initiatives to improve undergraduate student outcomes in STEM. One model for scalable reform is the inclusive Research Education Community (iREC). In an iREC, STEM faculty from colleges and universi

Externí odkaz: https://doaj.org/article/f50dca97413047c5972e7d31f6d2f587

Assessing effects of Cannabis on various neuropathologies: A systematic review

Autor: Suhrud Pathak, Jeyaram Bharathi Jeyabalan, Keyi Liu, Preston Cook, Bennett Lange, Shannon Kim, Rishi Nadar, Kiersten Ward, Courtney S. Watts Alexander, Ashwani Kumar, Kamal Dua, Timothy Moore, Jeyabalan Govindasamy, Muralikrishnan Dhanasekaran

Publikováno v: Journal of Ayurveda and Integrative Medicine, Vol 15, Iss 3, Pp 100911- (2024)

Natural bioactives possess a wide range of chemical structures that can exert a plethora of pharmacological and toxicological actions, resulting in neuroprotection or neurotoxicity. These pharmacodynamic properties can positively or negatively impact

Externí odkaz: https://doaj.org/article/73492e544e774757bcec645e8d35aacb

Investigating the mechanical stability of flexible metal–organic frameworks

Autor: Florencia A. Son, Kira M. Fahy, Madeleine A. Gaidimas, Courtney S. Smoljan, Megan C. Wasson, Omar K. Farha

Publikováno v: Communications Chemistry, Vol 6, Iss 1, Pp 1-8 (2023)

Abstract As we continue to develop metal–organic frameworks (MOFs) for potential industrial applications, it becomes increasingly imperative to understand their mechanical stability. Notably, amongst flexible MOFs, structure-property relationships

Externí odkaz: https://doaj.org/article/ddf7237cd0f1422b822ece57bfc8c38a

Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD

Autor: Michael R. Hicks, Xiangsheng Liu, Courtney S. Young, Kholoud Saleh, Ying Ji, Jinhong Jiang, Michael R. Emami, Ekaterina Mokhonova, Melissa J. Spencer, Huan Meng, April D. Pyle

Publikováno v: Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-14 (2023)

Abstract Skeletal muscle disease severity can often progress asymmetrically across muscle groups and heterogeneously within tissues. An example is Duchenne Muscular Dystrophy (DMD) in which lack of dystrophin results in devastating skeletal muscle wa

Externí odkaz: https://doaj.org/article/fc30c8af631a4308b39d8184e01496a3