Comparison of SARS-CoV-2 evolution in paediatric primary airway epithelial cell cultures compared with vero-derived cell lines

Autor: Bamford, Connor G.G., Broadbent, Lindsay, Aranday-Cortes, Elihu, McCabe, Mary, McKenna, James, Courtney, David G., Touzelet, Olivier, Ali, Ahlam, Roberts, Grace, Lopez Campos, Guillermo, Simpson, David, McCaughey, Conall, Fairley, Derek, Mills, Ken, Power, Ultan F.

SARS-CoV-2 can efficiently infect both children and adults, albeit with morbidity and mortality positively associated with increasing host age and presence of co-morbidities. SARS-CoV-2 continues to adapt to the human population, resulting in several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ec3dca49b27b55e4c23bab4d8ed9ba63
https://eprints.gla.ac.uk/264877/1/264877.pdf

Addition of m⁶A to SV40 late mRNAs enhances viral structural gene expression and replication.

Autor: Tsai, Kevin¹, Courtney, David G.¹, Cullen, Bryan R.¹ bryan.cullen@duke.edu

Publikováno v: PLoS Pathogens. 2/15/2018, Vol. 14 Issue 2, p1-23. 23p.

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Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy

Autor: Allen, Edwin H A, Courtney, David G, Atkinson, Sarah D, Moore, Johnny E, Mairs, Laura, Toftgaard Poulsen, Ebbe, Schiroli, Davide, Maurizi, Eleonora, Cole, Christian, Hickerson, Robyn P, James, John, Murgatroyd, Helen, Smith, Francis J D, MacEwen, Carrie, Enghild, Jan J, Nesbit, M Andrew, Leslie Pedrioli, Deena M, McLean, W H Irwin, Moore, C B Tara

Publikováno v: Allen, E H A, Courtney, D G, Atkinson, S D, Moore, J E, Mairs, L, Toftgaard Poulsen, E, Schiroli, D, Maurizi, E, Cole, C, Hickerson, R P, James, J, Murgatroyd, H, Smith, F J D, MacEwen, C, Enghild, J J, Nesbit, M A, Leslie Pedrioli, D M, McLean, W H I & Moore, C B T 2016, ' Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy ', Human Molecular Genetics, vol. 25, no. 6, pp. 1176-1191 . https://doi.org/10.1093/hmg/ddw001

Meesmann epithelial corneal dystrophy (MECD) is a rare autosomal dominant disorder caused by dominant-negative mutations within the KRT3 or KRT12 genes, which encode the cytoskeletal proteins keratin K3 and K12, respectively. To investigate the patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::0e94f9b7a735e017a136e79b7519b748
https://pure.au.dk/portal/da/publications/keratin-12-missense-mutation-induces-the-unfolded-protein-response-and-apoptosis-in-meesmann-epithelial-corneal-dystrophy(86a9fcf4-1fc6-4c24-9db2-ef10be5b3181).html