Oncogenic pathway signatures predict the risk of progression and recurrence in well-differentiated pancreatic neuroendocrine tumors.

Autor: Mederos MA; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA., Court CM; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, USA., Dipardo BJ; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA., Pisegna JR; Department of Molecular, Cellular, and Integrative Physiology, University of California Los Angeles, Los Angeles, California, USA., Dawson DW; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA., Joe Hines O; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA., Donahue TR; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, USA., Graeber TG; Department of Molecular, Cellular, and Integrative Physiology, University of California Los Angeles, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA.; California NanoSystems Institute, University of California, Los Angeles, California, USA., Girgis MD; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.; Department of Surgery, Veterans Health Administration, Greater Los Angeles, Los Angeles, California, USA., Tomlinson JS; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.; Department of Surgery, Veterans Health Administration, Greater Los Angeles, Los Angeles, California, USA.

Publikováno v: Journal of surgical oncology [J Surg Oncol] 2024 Aug 19. Date of Electronic Publication: 2024 Aug 19.

Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset.

Autor: Xu Y; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Nipper MH; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Dominguez AA; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Ye Z; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Akanuma N; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Lopez K; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Deng JJ; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Arenas D; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Sanchez A; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Sharkey FE; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Court CM; Division of Surgical Oncology and Endocrine Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Singhi AD; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA., Wang H; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, 55905, USA., Sun LZ; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Zheng S; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Chen Y; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Liu J; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. Liuj8@uthscsa.edu., Wang P; Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. wangp3@uthscsa.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 27; Vol. 15 (1), pp. 818. Date of Electronic Publication: 2024 Jan 27.

Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma.

Autor: Ecker BL; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey., Tao AJ; Weill Cornell Medical College, New York, New York., Janssen QP; Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Walch HS; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., Court CM; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Balachandran VP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York., Crane CH; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York., D'Angelica MI; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Drebin JA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Kingham TP; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Soares KC; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Vakiani E; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Gonen M; Department of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., O'Reilly EM; Weill Cornell Medical College, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Varghese AM; Weill Cornell Medical College, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer Research, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Jarnagin WR; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Wei AC; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Apr 03; Vol. 29 (7), pp. 1368-1374.

Group Care in the first 1000 days: implementation and process evaluation of contextually adapted antenatal and postnatal group care targeting diverse vulnerable populations in high-, middle- and low-resource settings.

Autor: Martens N; Leiden University Medical Centre, Leiden, Netherlands. n.martens@lumc.nl., Crone MR; Leiden University Medical Centre, Leiden, Netherlands., Hindori-Mohangoo A; Foundation for Perinatal Interventions and Research in Suriname, Paramaribo, Suriname., Hindori M; Foundation for Perinatal Interventions and Research in Suriname, Paramaribo, Suriname., Reis R; Leiden University Medical Centre, Leiden, Netherlands.; Amsterdam Institute for Global Health and Development (AIGHD), Amsterdam, Netherlands.; University of Cape Town, Cape Town, South Africa., Hoxha IS; Evidence Synthesis Group Prishtina, Prishtina, Republic of Kosovo.; Action for Mothers and Children, Prishtina, Republic of Kosovo., Abanga J; Presby Health Services, Accra, Ghana., Matthews S; University of Cape Town, Cape Town, South Africa., Berry L; University of Cape Town, Cape Town, South Africa., van der Kleij RMJJ; Leiden University Medical Centre, Leiden, Netherlands., van den Akker-van Marle ME; Leiden University Medical Centre, Leiden, Netherlands., van Damme A; Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Talrich F; Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Beeckman K; Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.; Universiteit Antwerpen, Antwerp, Belgium., Court CM; City University of London, London, UK., Rising SS; Group Care Global, Philadelphia, USA., Billings DL; Group Care Global, Philadelphia, USA., Rijnders M; Netherlands Organisation for Applied Scientific Research, The Hague, Netherlands.

Publikováno v: Implementation science communications [Implement Sci Commun] 2022 Nov 24; Vol. 3 (1), pp. 125. Date of Electronic Publication: 2022 Nov 24.

Alterations in Somatic Driver Genes Are Associated with Response to Neoadjuvant FOLFIRINOX in Patients with Localized Pancreatic Ductal Adenocarcinoma.

Autor: Ecker BL; From the Hepatopancreatobiliary Service, Department of Surgery (Ecker, Court, D'Angelica, Drebin, Jarnagin, Wei), Memorial Sloan Kettering Cancer Center, New York, NY., Court CM; From the Hepatopancreatobiliary Service, Department of Surgery (Ecker, Court, D'Angelica, Drebin, Jarnagin, Wei), Memorial Sloan Kettering Cancer Center, New York, NY., Janssen QP; Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands (Janssen)., Tao AJ; Weill Cornell Medical College, New York, NY (Tao)., D'Angelica MI; From the Hepatopancreatobiliary Service, Department of Surgery (Ecker, Court, D'Angelica, Drebin, Jarnagin, Wei), Memorial Sloan Kettering Cancer Center, New York, NY., Drebin JA; From the Hepatopancreatobiliary Service, Department of Surgery (Ecker, Court, D'Angelica, Drebin, Jarnagin, Wei), Memorial Sloan Kettering Cancer Center, New York, NY., Gonen M; Department of Biostatistics (Gonen), Memorial Sloan Kettering Cancer Center, New York, NY., O'Reilly EM; Department of Medicine (O'Reilly), Memorial Sloan Kettering Cancer Center, New York, NY.; David M. Rubenstein Center for Pancreatic Cancer Research, New York, NY (O'Reilly)., Jarnagin WR; From the Hepatopancreatobiliary Service, Department of Surgery (Ecker, Court, D'Angelica, Drebin, Jarnagin, Wei), Memorial Sloan Kettering Cancer Center, New York, NY., Wei AC; From the Hepatopancreatobiliary Service, Department of Surgery (Ecker, Court, D'Angelica, Drebin, Jarnagin, Wei), Memorial Sloan Kettering Cancer Center, New York, NY.

Publikováno v: Journal of the American College of Surgeons [J Am Coll Surg] 2022 Aug 01; Vol. 235 (2), pp. 342-349. Date of Electronic Publication: 2022 Apr 05.