Poly (lactide-co-glycolide) acid nanoencapsulation of a synthetic coumarin: cytotoxicity and bio-distribution in mice, in cancer cell line and interaction with calf thymus DNA as target

Autor: Asmita Samadder, Saili Paul, Durba Das, Anisur Rahman Khuda-Bukhsh, Soumya Sundar Bhattacharyya, Naoual Boujedaini, Arnab Kumar De

Publikováno v: Toxicology and applied pharmacology. 253(3)

Several naturally occurring coumarin compounds, including scopoletin (7 hydroxy-6 methoxycoumarin), of plant origin have been reported to have anti-cancer potentials. A related but chemically synthesized coumarin, 4-methyl-7-hydroxy coumarin (SC), wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965bfb001bc86870d1789c8f17d9a3a1
https://pubmed.ncbi.nlm.nih.gov/21549736

Uses of acetoacetanilide for the synthesis of thiophene derivatives with cytotoxic activities

Autor: R. A. Ibrahim

Publikováno v: Bulletin of the Chemical Society of Ethiopia, Vol 31, Iss 3, Pp 519-534 (2018)
Bulletin of the Chemical Society of Ethiopia; Vol 31, No 3 (2017); 519-534

The reaction of acetoacetanilide 1 with elemental sulfur and malononitrile 2 gave the thiophene derivative 3 . The latter was the key starting material for the synthesis of different thiophene and fused derivatives through its reaction with aryldiazo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fd0f58267586acb8c0bbb534703819
https://doi.org/10.4314/bcse.v31i3.16

Novel Coumarin-Indole Hybrids as Cytotoxic Candidates: Synthesis and Antiproliferative Activity.

Autor: Ismael, Sarah S.¹ sarahismael86@uomosul.edu.iq, Waheed, Noor Ahmed M.¹, Kasim, Seema Mahmood¹, Mustafa, Yasser Fakri¹

Publikováno v: Pharmacognosy Journal. Nov/Dec2023, Vol. 15 Issue 6, p1105-1111. 7p.

Systems biology approaches of Scopoletin reveal target potential biomarkers and its associated signaling pathways in colon cancer.

Autor: Sakthivel, Kunnathur Murugesan, Rasmi, Rajan Radha, Priya Dharshini, Loganathan Chandramani, Ramesh, Balasubramanian

Publikováno v: Journal of Applied Biology & Biotechnology (JABB); Sep2024, Vol. 12 Issue 5, p103-113, 11p

Nano-pelargonidin modulates p53/PARP/HSP 90/XRCC1 signaling axis to combat cypermethrin-induced genotoxicity and metabolic dysfunction in fish: a molecular docking predicted in vivo approach.

Autor: Sow, Priyanka, Dey, Sudatta, Dey, Rishita, Samadder, Asmita, Nandi, Sisir, Tarafdar, Debojyoti, Khuda-Bukhsh, Anisur Rahman

Publikováno v: Environmental Science: Nano; Jun2024, Vol. 11 Issue 6, p2397-2414, 18p