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HLA-DRB1*16

Autor: Nicoletti, Paola, Werk, Anneke, Sawle, Ashley, Shen, Yufeng, Urban, Thomas, Coulthard, Sally, Björnsson, Einar, Cascorbi, Ingolf, Floratos, Aris, Stammschulte, Thomas, Gundert-Remy, Ursula, Nelson, Matthew, Aithal, Guruprasad, Daly, Ann, Consortium, International Drug-Induced Liver Injury, Larrey, Dominique

Publikováno v: Pharmacogenetics and genomics, 26(5), 218-224. Lippincott Williams and Wilkins
Pharmacogenetics and Genomics
Pharmacogenetics and Genomics, Lippincott, Williams & Wilkins, 2016, 26 (5), pp.218-224. ⟨10.1097/FPC.0000000000000209⟩

Objective Flupirtine is a nonopioid analgesic with regulatory approval in a number of European countries. Because of the risk of serious liver injury, its use is now limited to short-term pain management. We aimed to identify genetic risk factors for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1039720a4134124063672648fbf70c
https://doi.org/10.1097/fpc.0000000000000209

The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase

Autor: Hall, Andrew G. ^{a, *}, Hamilton, Peter ^b, Minto, Lynne ^a, Coulthard, Sally A. ^a

Publikováno v: In Journal of Biochemical and Biophysical Methods 2001 47(1):65-71

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Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

Autor: Nicoletti, Paola, Aithal, Guruprasad P., Bjornsson, Einar S., Andrade, Raul J., Sawle, Ashley, Arrese, Marco, Barnhart, Huiman X., Bondon-Guitton, Emmanuelle, Hayashi, Paul H., Bessone, Fernando, Carvajal, Alfonso, Cascorbi, Ingolf, Cirulli, Elizabeth T., Chalasani, Naga, Conforti, Anita, Coulthard, Sally A., Daly, Mark J., Day, Christopher P., Dillon, John F., Fontana, Robert J., Grove, Jane I., Hallberg, Par, Hernandez, Nelia, Ibanez, Luisa, Kullak-Ublick, Gerd A., Laitinen, Tarja, Larrey, Dominique, Lucena, M. Isabel, Maitland-van der Zee, Anke H., Martin, Jennifer H., Molokhia, Mariam, Pirmohamed, Munir, Powell, Elizabeth E., Qin, Shengying, Serrano, Jose, Stephens, Camilla, Stolz, Andrew, Wadelius, Mia, Watkins, Paul B., Floratos, Aris, Shen, Yufeng, Nelson, Matthew R., Urban, Thomas J., Daly, Ann K., Int Drug-Induced Liver Injury Cons, Drug-Induced Liver Injury Network, Int Serious Adverse Events Consort

Publikováno v: Nicoletti, P, Aithal, G P, Bjornsson, E S, Andrade, R J, Sawle, A, Arrese, M, Barnhart, H X, Bondon-Guitton, E, Hayashi, P H, Bessone, F, Carvajal, A, Cascorbi, I, Cirulli, E T, Chalasani, N, Conforti, A, Coulthard, S A, Daly, M J, Day, C P, Dillon, J F, Fontana, R J, Grove, J I, Hallberg, P, Hernández, N, Ibáñez, L, Kullak-Ublick, G A, Laitinen, T, Larrey, D, Lucena, M I, Maitland-van der Zee, A H, Martin, J H, Molokhia, M, Pirmohamed, M, Powell, E E, Qin, S, Serrano, J, Stephens, C, Stolz, A, Wadelius, M, Watkins, P B, Floratos, A, Shen, Y, Nelson, M R, Urban, T J & Daly, A K 2017, ' Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study ', Gastroenterology, vol. 152, no. 5, pp. 1078-1089 . https://doi.org/10.1053/j.gastro.2016.12.016
Gastroenterology
Gastroenterology, 152(5), 1078-1089. W.B. Saunders Ltd

Background & Aims We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. Methods We performed a GWAS of 862 perso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fb7efe69389e2c91a552ade12761d
http://www.gastrojournal.org/article/S0016508516355305/pdf