A randomised, placebo-controlled, phase III trial of leniolisib in activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS): Adolescent and adult subgroup analysis.

Autor: Rao VK; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. Electronic address: korao@niaid.nih.gov., Šedivá A; Department of Immunology, Motol University Hospital, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic., Dalm VASH; Department of Internal Medicine, Division of Allergy and Clinical Immunology; Department of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands., Plebani A; Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia, Brescia, Italy., Schuetz C; Pediatric Immunology, Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Shcherbina A; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Trizzino A; Department of Pediatric Hematology and Oncology, ARNAS Ospedali Civico Di Cristina Benfratelli Hospital, Palermo, Italy., Zharankova Y; Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus., Orpia A; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Kulm E; Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Bethesda, MD, United States., Webster S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Körholz J; Pediatric Immunology, Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Lougaris V; Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia, Brescia, Italy., Rodina Y; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Conlon N; Wellcome Trust Clinical Research Facility, St. James's Hospital and School of Medicine, Trinity College Dublin, Ireland., Coulter T; Regional Immunology Services of Northern Ireland, Belfast Health and Social Care Trust, United Kingdom., Bradt J; Pharming Healthcare Inc, Warren, NJ, United States., Relan A; Pharming Healthcare Inc, Warren, NJ, United States., Uzel G; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Publikováno v: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2025 Jan; Vol. 270, pp. 110400. Date of Electronic Publication: 2024 Nov 17.

Insights into the length and breadth of methodologies harnessed to study human telomeres.

Autor: Coulter T; Centre for Public Health, Queen's University Belfast, Institute of Clinical Sciences - Block A, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BJ, UK., Hill C; Centre for Public Health, Queen's University Belfast, Institute of Clinical Sciences - Block A, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BJ, UK. c.hill@qub.ac.uk., McKnight AJ; Centre for Public Health, Queen's University Belfast, Institute of Clinical Sciences - Block A, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BJ, UK. a.j.mcknight@qub.ac.uk.

Publikováno v: Biomarker research [Biomark Res] 2024 Oct 22; Vol. 12 (1), pp. 127. Date of Electronic Publication: 2024 Oct 22.

A National Survey of Hereditary Angioedema and Acquired C1 Inhibitor Deficiency in the United Kingdom.

Autor: Yong PFK; Department of Allergy and Clinical Immunology, Frimley Health NHS Foundation Trust, Frimley, United Kingdom. Electronic address: patrick.yong@nhs.net., Coulter T; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, United Kingdom., El-Shanawany T; Department of Immunology, University Hospital of Wales, Cardiff, Wales, United Kingdom., Garcez T; Department of Immunology, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Hackett S; Department of Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Jain R; Department of Clinical Immunology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Kiani-Alikhan S; Department of Immunology, Barts Health NHS Trust, London, United Kingdom., Manson A; Department of Clinical Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Noorani S; Department of Immunology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom., Stroud C; Regional Department of Immunology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom., Symons C; Department of Clinical Immunology and Allergy, University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom., Sargur R; Department of Clinical Immunology and Allergy, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom., Steele C; Department of Clinical Immunology, Ninewells Hospital, NHS Tayside, Dundee, United Kingdom., Alachkar H; Department of Immunology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom., Anantharachagan A; Department of Immunology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom., Arkwright PD; Department of Paediatric Allergy and Immunology, Royal Manchester Children's Hospital, Manchester, United Kingdom., Bernatoniene J; Department of Paediatric Immunology, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom., Bhole M; Department of Immunology, The Dudley Group NHS Foundation Trust, Dudley, United Kingdom., Brown L; Department of Immunology and infectious Diseases, Royal Hospital for Children and Young People, NHS Lothian, Edinburgh, United Kingdom., Buckland M; Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom., Burns S; Department of Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom., Chopra C; Department of Clinical Immunology, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom., Darroch J; Department of Immunology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom., Drewe E; Department of Clinical Immunology and Allergy, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Edmonds J; Department of Clinical Immunology, Ninewells Hospital, NHS Tayside, Dundee, United Kingdom., Ekbote A; Department of Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Elkhalifa S; Department of Clinical Immunology, Salford Royal NHS Foundation Trust, Manchester, United Kingdom., Goddard S; Department of Clinical Immunology, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom., Grosse-Kreul D; Department of Clinical Immunology and Allergy, King's College Hospital NHS Foundation Trust, London, United Kingdom., Gurugama P; Department of Clinical Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Hague R; Department of Paediatric Immunology and Infectious Diseases, Royal Hospital for Sick Children, Glasgow, United Kingdom., Herriot R; Department of Immunology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom., Herwadkar A; Department of Clinical Immunology, Salford Royal NHS Foundation Trust, Manchester, United Kingdom., Hughes SM; Department of Paediatric Allergy and Immunology, Royal Manchester Children's Hospital, Manchester, United Kingdom., Jones L; Department of Immunology and infectious Diseases, Royal Hospital for Children and Young People, NHS Lothian, Edinburgh, United Kingdom., Lear S; Department of Clinical Immunology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom., McDermott E; Department of Clinical Immunology and Allergy, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Kham Murng SH; Department of Clinical Immunology, Epsom and St Helier University Hospitals NHS Trust, Epsom, United Kingdom., Price A; Department of Clinical Immunology and Allergy, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom., Redenbaugh V; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, United Kingdom., Richter A; Department of Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Riordan A; Department of Paediatric Infectious Diseases and Immunology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom., Shackley F; Department of Immunology and Infectious Diseases, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom., Stichbury J; Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Springett D; Department of Clinical Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Tarzi MD; Department of Immunology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom., Thomas M; Department of Clinical Immunology, Queen Elizabeth University Hospital, Glasgow, United Kingdom., Vijayadurai P; Department of Immunology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom., Worth A; Department of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Publikováno v: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2023 Aug; Vol. 11 (8), pp. 2476-2483. Date of Electronic Publication: 2023 May 03.

A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome.

Autor: Rao VK; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Webster S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Šedivá A; Department of Immunology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic., Plebani A; Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia, Brescia, Italy., Schuetz C; Department of Pediatric Immunology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Shcherbina A; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Conlon N; Wellcome Trust Clinical Research Facility, St. James's Hospital, and Department of Clinical Immunology, Trinity College Dublin, Dublin, Ireland., Coulter T; Regional Immunology Services of Northern Ireland, Belfast Health and Social Care Trust, Belfast, United Kingdom., Dalm VA; Division of Allergy and Clinical Immunology, Department of Internal Medicine, and Department of Immunology, Erasmus Medical Center University Medical Center, Rotterdam, the Netherlands., Trizzino A; Department of Pediatric Hematology and Oncology, ARNAS Ospedali Civico Di Cristina Benfratelli Hospital, Palermo, Italy., Zharankova Y; Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus., Kulm E; Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Bethesda, MD., Körholz J; Department of Pediatric Immunology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Lougaris V; Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia, Brescia, Italy., Rodina Y; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia., Radford K; Novartis Pharmaceuticals UK Limited, London, United Kingdom., Bradt J; Pharming Healthcare Inc, Warren, NJ., Kucher K; Novartis Institutes for Biomedical Research, Basel, Switzerland., Relan A; Pharming Healthcare Inc, Warren, NJ., Holland SM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Lenardo MJ; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Uzel G; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Publikováno v: Blood [Blood] 2023 Mar 02; Vol. 141 (9), pp. 971-983.

Targeting Ultrasmall Gold Nanoparticles with cRGD Peptide Increases the Uptake and Efficacy of Cytotoxic Payload.

Autor: Perrins RD; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., McCarthy LA; School of Life Sciences, University of Lincoln, Joseph Banks Laboratories, Green Lane, Lincoln LN6 7DL, UK., Robinson A; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Spry KL; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Cognet V; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Ferreira A; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Porter J; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Garcίa CE; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Rodriguez MÁ; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Lopez D; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Perera I; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Conlon K; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Barrientos A; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Coulter T; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Pace A; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Hale SJM; Midatech Pharma Plc, 1 Caspian Point, Caspian Way, Cardiff CF10 4DQ, UK., Ferrari E; School of Life Sciences, University of Lincoln, Joseph Banks Laboratories, Green Lane, Lincoln LN6 7DL, UK., Bachrati CZ; School of Life Sciences, University of Lincoln, Joseph Banks Laboratories, Green Lane, Lincoln LN6 7DL, UK.

Publikováno v: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Nov 15; Vol. 12 (22). Date of Electronic Publication: 2022 Nov 15.