Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis.

Autor: Pinette JA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Myers JW; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Park WY; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Bryant HG; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Eddie AM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Wilson GA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Montufar C; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Shaikh Z; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Vue Z; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Nunn ER; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Bessho R; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cottam MA; Creative Data Solutions, Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA., Haase VH; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Research and Medical Services, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Hinton AO; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Spinelli JB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Cartailler JP; Creative Data Solutions, Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA., Zaganjor E; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Diabetes Research Center, Vanderbilt University, Nashville, TN, USA. Electronic address: elma.zaganjor@vanderbilt.edu.

Publikováno v: Journal of lipid research [J Lipid Res] 2024 Oct; Vol. 65 (10), pp. 100641. Date of Electronic Publication: 2024 Sep 06.

Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations.

Autor: Pierro EW; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN., Cottam MA; Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN., An H; Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN., Lehmann BD; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN., Pietenpol JA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Department of Biochemistry, Vanderbilt University, Nashville, TN., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Makowski L; Department of Medicine, Division of Hematology-Oncology, University of Tennessee Health Science Center, Memphis, TN, 31863, USA., Rathmell JC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN., Fingleton B; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Department of Pharmacology, Vanderbilt University, Nashville, TN., Hasty AH; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN.; Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN.; Department of Internal Medicine, Touchstone Diabetes Center, UT Southwestern, Dallas, TX.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 27. Date of Electronic Publication: 2024 Sep 27.

Author Correction: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.

Autor: Bader JE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Wolf MM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Lupica-Tondo GL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Madden MZ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Reinfeld BI; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Arner EN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hathaway ES; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Steiner KK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Needle GA; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Hatem Z; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Landis MD; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Faneuff EE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Blackman A; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Wolf EM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Cottam MA; Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Ye X; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Bates ME; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Smart K; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Wang W; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Pinheiro LV; Department of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Christofides A; Department of Medicine, Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University, Boston, MA, USA., Smith D; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada., Boussiotis VA; Department of Medicine, Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University, Boston, MA, USA., Haake SM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Beckermann KE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Wellen KE; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reinhart-King CA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Serezani CH; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Lee CH; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada., Aubrey C; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada., Chen H; Department of Biostatistics, Vanderbilt University, Nashville, TN, USA., Rathmell WK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Hasty AH; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; US Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Rathmell JC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. jeff.rathmell@vumc.org.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA. jeff.rathmell@vumc.org.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. jeff.rathmell@vumc.org.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. jeff.rathmell@vumc.org.

Publikováno v: Nature [Nature] 2024 Jul; Vol. 631 (8022), pp. E16.

Gene expression plasticity of the mammalian brain circadian clock in response to photoperiod.

Autor: Cox OH, Gianonni-Guzmán MA, Cartailler JP, Cottam MA, McMahon DG

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 25. Date of Electronic Publication: 2024 Mar 25.

Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress.

Autor: Osipovich AB; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA., Zhou FY; College of Arts and Sciences, Vanderbilt University, Nashville, TN 37232, USA., Chong JJ; College of Arts and Sciences, Vanderbilt University, Nashville, TN 37232, USA., Trinh LT; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA., Cottam MA; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA., Shrestha S; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA., Cartailler JP; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA., Magnuson MA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: mark.magnuson@vanderbilt.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2023 Dec; Vol. 78, pp. 101811. Date of Electronic Publication: 2023 Sep 26.