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Akademický článek

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes

Autor: Sárvári Miklós, Hrabovszky Erik, Kalló Imre, Solymosi Norbert, Likó István, Berchtold Nicole, Cotman Carl, Liposits Zsolt

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 264 (2012)

Abstract Background The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal corte

Externí odkaz: https://doaj.org/article/9c4c11a250c24c8fb1c5bb73ecad08d2

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Akademický článek

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Autor: Cribbs David H, Berchtold Nicole C, Perreau Victoria, Coleman Paul D, Rogers Joseph, Tenner Andrea J, Cotman Carl W

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 179 (2012)

Abstract Background This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer’s disease (AD). Methods In a well-powered microarray study of young (20

Externí odkaz: https://doaj.org/article/edd7a94efcf845f185b1875a910a4597

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Akademický článek

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

Autor: Cribbs David H, Parachikova Anna I, Poon Wayne W, Nichol Kathryn E, Glabe Charles G, Cotman Carl W

Publikováno v: Journal of Neuroinflammation, Vol 5, Iss 1, p 13 (2008)

Abstract Background Inflammation is associated with Aβ pathology in Alzheimer's disease (AD) and transgenic AD models. Previously, it has been demonstrated that chronic stimulation of the immune response induces pro-inflammatory cytokines IL-1β and

Externí odkaz: https://doaj.org/article/ae0a6c28daa64aefbf463bdb6f731680

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Akademický článek

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Autor: Rasool Suhail, Thompson Jennifer L, Breydo Leonid, Wu Jessica, Margol Lawrence, Necula Mihaela, Cotman Carl W, Saing Tommy, Sarsoza Floyd, Head Elizabeth, Kayed Rakez, Gurlo Tatyana, Butler Peter, Glabe Charles G

Publikováno v: Molecular Neurodegeneration, Vol 2, Iss 1, p 18 (2007)

Abstract Background Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits,

Externí odkaz: https://doaj.org/article/6c0d8b6b99604fbc9e7448c224daffaf

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