Obesity Promotes the Ceramide-Mediated NADPH Oxidase in Acute Myeloid Leukemia.

Autor: Wang W; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta GA 30322 USA., Sabol RJ; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Day AM; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Hathorn TG; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Clark MN; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Connell SE; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Mantis EA; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Traore M; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Siciliano JM; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Arsenault EJ; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Labrecque NT; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Sullivan EC; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Cote AL; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139 USA., Toran PT; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Barth BM; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.; Department of Natural Sciences, University of Alaska Southeast, Juneau, AK 99801 USA.

Publikováno v: Journal of blood disorders and malignancies [J Blood Disord Malig] 2024; Vol. 2 (1). Date of Electronic Publication: 2024 Apr 15.

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia.

Autor: Barth BM; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH.; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Wang W; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Toran PT; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Fox TE; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA., Annageldiyev C; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Ondrasik RM; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Keasey NR; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Brown TJ; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Devine VG; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Sullivan EC; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Cote AL; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Papakotsi V; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Tan SF; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Shanmugavelandy SS; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Deering TG; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA., Needle DB; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Stern ST; Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick National Laboratory for Cancer Research, Frederick, MD., Zhu J; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA., Liao J; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA., Viny AD; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Feith DJ; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Levine RL; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Wang HG; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Pediatric Molecular Oncology Program, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA; and., Loughran TP Jr; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Sharma A; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Kester M; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA.; nanoSTAR Institute, University of Virginia, Charlottesville, VA., Claxton DF; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.

Publikováno v: Blood advances [Blood Adv] 2019 Sep 10; Vol. 3 (17), pp. 2598-2603.