Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Costin N. Antonescu"'
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently con
Externí odkaz:
https://doaj.org/article/a76bca4ec1bb40f1bbe42379e8c8888d
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105883- (2023)
Summary: Ultrasound-stimulated microbubble (USMB) treatment is a promising strategy for cancer therapy. USMB promotes drug delivery by sonoporation and enhanced endocytosis, and also impairs cell viability. However, USMB elicits heterogeneous effects
Externí odkaz:
https://doaj.org/article/99b6f6c8cfa5494fbaea15f56939ff51
Autor:
Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B. McPhee, Russell D. Viirre, Andrew Haller, Roberto J. Botelho, Raffi Karshafian, Sarah A. Sabatinos, Gregory D. Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S. MacKinnon, Bo Wang, Costin N. Antonescu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronavi
Externí odkaz:
https://doaj.org/article/6fc7b459daf94a499be2325b0bbff79f
Autor:
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic pain has been widely recognized as a major public health problem that impacts multiple aspects of patient quality of life. Unfortunately, chronic pain is often resistant to conventional analgesics, which are further limited by their various s
Externí odkaz:
https://doaj.org/article/30cb61b8aa824cab8b21e0995f05f8e9
Autor:
Costin N. Antonescu, Allen P. Liu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Externí odkaz:
https://doaj.org/article/e7cac4c6435440a2b9cb2402695e6260
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions, including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine kinases are critical regulators of Akt, as a result of activation of p
Externí odkaz:
https://doaj.org/article/400e9b3690f542debc34246351069bce
Publikováno v:
Communicative & Integrative Biology, Vol 9, Iss 3 (2016)
Receptor tyrosine kinases, such as the epidermal growth factor (EGF) receptor (EGFR) and Met lead to activation of intracellular signals including Akt, a critical regulator of cell survival, metabolism and proliferation. Upon binding their respective
Externí odkaz:
https://doaj.org/article/a6fc9b445e6643d1b751feeabb497261
Autor:
Rehman Ata, Costin N. Antonescu
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 1, p 189 (2017)
Integrins are important regulators of cell survival, proliferation, adhesion and migration. Once activated, integrins establish a regulated link between the extracellular matrix and the cytoskeleton. Integrins have well-established functions in cance
Externí odkaz:
https://doaj.org/article/99ffa79632ad4be1b1f82d4ee553db3f
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology that is stimulated by multiple distinct ligands. Although ligands bind to EGFR while the receptor is exposed on the plasma membrane, EGFR incorporation into endosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4e041061d47d780fb2239428ebab3
https://doi.org/10.1101/2023.05.09.539827
https://doi.org/10.1101/2023.05.09.539827
Autor:
Costin N. Antonescu, Bo Wang, Stephen S. MacKinnon, Vijay Shahani, Jean-Philippe Julien, Andreas Windemuth, Seyed Ali Madani Tonekaboni, Gregory D. Fairn, Sarah A. Sabatinos, Raffi Karshafian, Roberto Botelho, Andrew Haller, Russell D. Viirre, Joseph B. McPhee, Rahul Misra, Kyle Cheung, Sikander Hayat, Hassaan Maan, Edurne Rujas, Mehran Karimzadeh, Dar’ya S. Redka, Haotian Cui, Michael G. Sugiyama
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a129474d5f09baee846b06163aa1f9
https://doi.org/10.32920/21982913.v1
https://doi.org/10.32920/21982913.v1