Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Costin N Antonescu"'
Autor:
Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa CB Oliveira, Aisha N Rekab, Mathieu JF Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia LM Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan
Publikováno v:
eLife, Vol 12 (2024)
Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumor pheochromocytoma (PCC) can be cau
Externí odkaz:
https://doaj.org/article/56671c5952a34e068944e75893122071
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156754 (2016)
Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations. USMB treatment elicits en
Externí odkaz:
https://doaj.org/article/f881606d10264a379a7f3dc161b17505
Autor:
Eden Ross, Rehman Ata, Thanusi Thavarajah, Sergei Medvedev, Peter Bowden, John G Marshall, Costin N Antonescu
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128013 (2015)
The cell surface proteome controls numerous cellular functions including cell migration and adhesion, intercellular communication and nutrient uptake. Cell surface proteins are controlled by acute changes in protein abundance at the plasma membrane t
Externí odkaz:
https://doaj.org/article/6014dc7c170644e3a82f62619f7c2a5a
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently con
Externí odkaz:
https://doaj.org/article/a76bca4ec1bb40f1bbe42379e8c8888d
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105883- (2023)
Summary: Ultrasound-stimulated microbubble (USMB) treatment is a promising strategy for cancer therapy. USMB promotes drug delivery by sonoporation and enhanced endocytosis, and also impairs cell viability. However, USMB elicits heterogeneous effects
Externí odkaz:
https://doaj.org/article/99b6f6c8cfa5494fbaea15f56939ff51
Autor:
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic pain has been widely recognized as a major public health problem that impacts multiple aspects of patient quality of life. Unfortunately, chronic pain is often resistant to conventional analgesics, which are further limited by their various s
Externí odkaz:
https://doaj.org/article/30cb61b8aa824cab8b21e0995f05f8e9
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology that is stimulated by multiple distinct ligands. Although ligands bind to EGFR while the receptor is exposed on the plasma membrane, EGFR incorporation into endosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4e041061d47d780fb2239428ebab3
https://doi.org/10.1101/2023.05.09.539827
https://doi.org/10.1101/2023.05.09.539827
Autor:
Costin N. Antonescu, Bo Wang, Stephen S. MacKinnon, Vijay Shahani, Jean-Philippe Julien, Andreas Windemuth, Seyed Ali Madani Tonekaboni, Gregory D. Fairn, Sarah A. Sabatinos, Raffi Karshafian, Roberto Botelho, Andrew Haller, Russell D. Viirre, Joseph B. McPhee, Rahul Misra, Kyle Cheung, Sikander Hayat, Hassaan Maan, Edurne Rujas, Mehran Karimzadeh, Dar’ya S. Redka, Haotian Cui, Michael G. Sugiyama
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a129474d5f09baee846b06163aa1f9
https://doi.org/10.32920/21982913.v1
https://doi.org/10.32920/21982913.v1
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156754 (2016)
PLoS ONE
PLoS ONE
Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations. USMB treatment elicits en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1631bc38b0cb0560e30b7a6b9ff17f
https://doi.org/10.32920/14638422
https://doi.org/10.32920/14638422
Publikováno v:
Journal of Cell Science. 136
The epidermal growth factor receptor (EGFR) controls many cellular functions. Upon binding its ligand, the receptor undergoes dimerization, phosphorylation and activation of signals including the phosphoinositide-3-kinase (PI3K)–Akt pathway. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06271a4192617b04179959ec16e45c75
https://doi.org/10.1242/jcs.260133
https://doi.org/10.1242/jcs.260133