Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics.

Autor: Karbasi AB; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Barfuss JD; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Morgan TC; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Collins D; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Costenbader DA; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Dennis DG; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Hinman A; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Ko K; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Messina C; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA.; Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Nguyen KC; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Schugar RC; Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Stein KA; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Williams BB; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Xu H; Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Annes JP; Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Smith M; Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA. mxsmith@stanford.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 01; Vol. 15 (1), pp. 8487. Date of Electronic Publication: 2024 Oct 01.