A low residue nutritive supplement as an alternative to feed withdrawal in broilers: efficacy for gastrointestinal tract emptying and maintenance of live weight prior to slaughter

Autor: Farhat, A, Edward, ME, Costell, MH, Hadley, JA, Walker, PN, Vasilatos-Younken, R

Publikováno v: In Poultry Science 1 September 2002 81(9):1406-1414

Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury.

Autor: Bihari S; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.; Intensive and Critical Care Unit, Flinders Medical Centre, Flinders Drive, Bedford Park, SA, 5042, Australia., Costell MH; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Bouchier T; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia., Behm DJ; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Burgert M; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Ye G; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Bersten AD; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.; Intensive and Critical Care Unit, Flinders Medical Centre, Flinders Drive, Bedford Park, SA, 5042, Australia., Puukila S; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia., Cavallaro E; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia., Sprecher DL; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Dixon DL; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia. dani.dixon@flinders.edu.au.; Intensive and Critical Care Unit, Flinders Medical Centre, Flinders Drive, Bedford Park, SA, 5042, Australia. dani.dixon@flinders.edu.au.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 May; Vol. 397 (5), pp. 3461-3475. Date of Electronic Publication: 2023 Nov 15.

Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

Autor: Brooks CA; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Barton LS; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Behm DJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Brnardic EJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Costell MH; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Holt DA; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Jolivette LJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Matthews JM; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., McAtee JJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., McCleland BW; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Patterson JR; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Pero JE; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Rivero RA; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Roethke TJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Sanchez RM; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Shenje R; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Terrell LR; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Lawhorn BG; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Oct 24; Vol. 62 (20), pp. 9270-9280. Date of Electronic Publication: 2019 Oct 09.

Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4).

Autor: Brnardic EJ, Ye G, Brooks C, Donatelli C, Barton L, McAtee J, Sanchez RM, Shu A, Erhard K, Terrell L, Graczyk-Millbrandt G, He Y, Costell MH, Behm DJ, Roethke T, Stoy P, Holt DA, Lawhorn BG

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Nov 08; Vol. 61 (21), pp. 9738-9755. Date of Electronic Publication: 2018 Oct 18.

Chronic inhibition of 11 β -hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome.

Autor: Schnackenberg CG; Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, UW2521, PO Box 1539, 709 Swedeland Road, King of Prussia, PA 19406-0939, USA., Costell MH, Krosky DJ, Cui J, Wu CW, Hong VS, Harpel MR, Willette RN, Yue TL

Publikováno v: BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 427640. Date of Electronic Publication: 2013 Mar 18.