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Akademický článek

Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury.

Autor: Bihari S; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.; Intensive and Critical Care Unit, Flinders Medical Centre, Flinders Drive, Bedford Park, SA, 5042, Australia., Costell MH; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Bouchier T; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia., Behm DJ; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Burgert M; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Ye G; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Bersten AD; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.; Intensive and Critical Care Unit, Flinders Medical Centre, Flinders Drive, Bedford Park, SA, 5042, Australia., Puukila S; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia., Cavallaro E; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia., Sprecher DL; GlaxoSmithKline (GSK), 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USA., Dixon DL; College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia. dani.dixon@flinders.edu.au.; Intensive and Critical Care Unit, Flinders Medical Centre, Flinders Drive, Bedford Park, SA, 5042, Australia. dani.dixon@flinders.edu.au.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 May; Vol. 397 (5), pp. 3461-3475. Date of Electronic Publication: 2023 Nov 15.

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Akademický článek

A low residue nutritive supplement as an alternative to feed withdrawal in broilers: efficacy for gastrointestinal tract emptying and maintenance of live weight prior to slaughter

Autor: Farhat, A, Edward, ME, Costell, MH, Hadley, JA, Walker, PN, Vasilatos-Younken, R

Publikováno v: In Poultry Science 1 September 2002 81(9):1406-1414

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Akademický článek

Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo.

Autor: Xu X; GlaxoSmithKline, Collegeville, Pennsylvania., Goyal N; GlaxoSmithKline, Collegeville, Pennsylvania., Costell MH; GlaxoSmithKline, Collegeville, Pennsylvania., Roethke T; GlaxoSmithKline, Collegeville, Pennsylvania., James CH; GlaxoSmithKline, Collegeville, Pennsylvania., Thorneloe KS; GlaxoSmithKline, Collegeville, Pennsylvania., Patterson J; GlaxoSmithKline, Collegeville, Pennsylvania., Stoy P; GlaxoSmithKline, Collegeville, Pennsylvania., Goodman K; GlaxoSmithKline, Collegeville, Pennsylvania., Sprecher DL; GlaxoSmithKline, Collegeville, Pennsylvania., Behm DJ; GlaxoSmithKline, Collegeville, Pennsylvania david.j.behm@gsk.com.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Mar; Vol. 376 (3), pp. 436-443. Date of Electronic Publication: 2020 Dec 29.

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Akademický článek

Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

Autor: Brooks CA; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Barton LS; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Behm DJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Brnardic EJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Costell MH; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Holt DA; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Jolivette LJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Matthews JM; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., McAtee JJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., McCleland BW; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Patterson JR; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Pero JE; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Rivero RA; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Roethke TJ; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Sanchez RM; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Shenje R; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Terrell LR; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States., Lawhorn BG; Heart Failure Discovery Performance Unit and Flexible Discovery Unit , GlaxoSmithKline , Collegeville , Pennsylvania 19426 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Oct 24; Vol. 62 (20), pp. 9270-9280. Date of Electronic Publication: 2019 Oct 09.

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Akademický článek

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11209-11220. Date of Electronic Publication: 2018 Dec 12.

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Akademický článek

Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4).

Autor: Brnardic EJ, Ye G, Brooks C, Donatelli C, Barton L, McAtee J, Sanchez RM, Shu A, Erhard K, Terrell L, Graczyk-Millbrandt G, He Y, Costell MH, Behm DJ, Roethke T, Stoy P, Holt DA, Lawhorn BG

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Nov 08; Vol. 61 (21), pp. 9738-9755. Date of Electronic Publication: 2018 Oct 18.

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Akademický článek

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.

Autor: Thalji RK; Department of Chemistry, Heart Failure Disease Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA., McAtee JJ, Belyanskaya S, Brandt M, Brown GD, Costell MH, Ding Y, Dodson JW, Eisennagel SH, Fries RE, Gross JW, Harpel MR, Holt DA, Israel DI, Jolivette LJ, Krosky D, Li H, Lu Q, Mandichak T, Roethke T, Schnackenberg CG, Schwartz B, Shewchuk LM, Xie W, Behm DJ, Douglas SA, Shaw AL, Marino JP Jr

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Jun 15; Vol. 23 (12), pp. 3584-8. Date of Electronic Publication: 2013 Apr 16.

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Akademický článek

Chronic inhibition of 11 β -hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome.

Autor: Schnackenberg CG; Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, UW2521, PO Box 1539, 709 Swedeland Road, King of Prussia, PA 19406-0939, USA., Costell MH, Krosky DJ, Cui J, Wu CW, Hong VS, Harpel MR, Willette RN, Yue TL

Publikováno v: BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 427640. Date of Electronic Publication: 2013 Mar 18.

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Akademický článek

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

Autor: Costell MH; Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area Unit, GlaxoSmithKline King of Prussia, PA, USA., Ancellin N, Bernard RE, Zhao S, Upson JJ, Morgan LA, Maniscalco K, Olzinski AR, Ballard VL, Herry K, Grondin P, Dodic N, Mirguet O, Bouillot A, Gellibert F, Coatney RW, Lepore JJ, Jucker BM, Jolivette LJ, Willette RN, Schnackenberg CG, Behm DJ

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2012 Jul 05; Vol. 3, pp. 128. Date of Electronic Publication: 2012 Jul 05 (Print Publication: 2012).

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