Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Costas Schulze"'
Autor:
Costas Schulze, Jonathan Cena, Ross T. Tsuyuki, Courtney Bryden, Michele M. Castro, Shoa H. Wang, Arulmozhi D. Kandasamy, Barry A. Finegan, Arvind Koshal, Richard Schulz
Publikováno v:
Critical Care Medicine. 41:2512-2520
Matrix metalloproteinase-2 proteolyzes intracellular proteins in the heart and induces acute myocardial contractile dysfunction in ischemia-reperfusion injury. Doxycycline, a matrix metalloproteinase inhibitor, prevented matrix metalloproteinase-2-in
Autor:
Nitin Ghorpade, Costas Schulze, Linda Stang, Arvind Koshal, Wai S. Etches, Shao Hua Wang, Lin Han
Publikováno v:
Journal of Cardiac Surgery. 24:363-368
BACKGROUND The interaction of blood with foreign artificial surfaces during cardiopulmonary bypass (CPB) has been recognized as a major stimulus in evoking a systemic inflammatory and metabolic response. Phosphorylcholine (PC) is a new-generation coa
Autor:
Grzegorz Sawicki, Jolanta Sawicka, Hernando Leon, Richard Schulz, Meltem Sariahmetoglu, Paul G. Scott, Costas Schulze, Danuta Szczesna-Cordary
Publikováno v:
Circulation. 112:544-552
Background— Matrix metalloproteinase-2 (MMP-2) contributes to cardiac dysfunction resulting from ischemia-reperfusion (I/R) injury. MMP-2 not only remodels the extracellular matrix but also acts intracellularly in I/R by degrading troponin I. Wheth
Autor:
Richard Schulz, Gianna Ferrari-Vivaldi, Manoj M. Lalu, Costas Schulze, Tiziana Bachetti, Evasio Pasini, Mario Ferrari-Vivaldi
Publikováno v:
European Heart Journal. 26:27-35
Aims Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate matrix remodelling in the heart and play a pivotal role in myocardial dysfunction immediately following ischaemia–reperfusion injury ex vivo in rats.
Autor:
Grzegorz Sawicki, Wenjie Wang, Richard Schulz, Costas Schulze, Wilma L. Suarez-Pinzon, Jolanta Sawicka
Publikováno v:
Circulation. 107:2487-2492
Background— We have previously reported that matrix metalloproteinase-2 (MMP-2) contributes to myocardial ischemia-reperfusion injury by degradation of troponin I, a regulatory element of the contractile proteins. MMP activities are also tightly re
Autor:
Richard Schulz, Grzegorz Sawicki, Costas Schulze, Jason R.B. Dyck, Wilma L. Suarez-Pinzon, Wenjie Wang
Publikováno v:
Circulation. 106:1543-1549
Background— Matrix metalloproteinases are best recognized for their ability to degrade the extracellular matrix in both physiological and pathological conditions. However, recent findings indicate that some of them are also involved in mediating ac
Autor:
N. Conrad, Wolfgang von Scheidt, Stephen M. Wildhirt, Michael Weis, G. Rieder, S. Pehlivanli, Bruno Reichart, Costas Schulze, Georg Enders
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 19:840-847
Objective: Coronary endothelial dysfunction may precede morphological changes in both the epicardial conduit and microvascular resistance vessels in heart transplant recipients. Since the development of transplant atherosclerosis is the major limitin
Publikováno v:
Zeitschrift f�r Herz-, Thorax- und Gef��chirurgie. 15:7-13
Hintergrund Das operative Trauma und die Verwendung der extrakorporalen Zirkulation (EKZ) wahrend herzchirurgischer Eingriffe sind mit einer systemischen inflammatorischen Reaktion des Organismus verbunden. Die vorliegende Studie untersucht die Effek
Autor:
Bruno Reichart, Paolo Brenner, A. Schütz, Christina M Schulz, K. Egi, Stephen M. Wildhirt, Helmut Mair, Costas Schulze
Publikováno v:
Shock. 16:55-59
Cardiopulmonary bypass (CPB) and operative trauma are associated with increased expression of proinflammatory mediators. We determined the relative contribution of CPB on activation of cytokines and adhesion molecules in patients undergoing coronary
Autor:
Michael Weis, W. von Scheidt, N. Conrad, G. Rieder, Kai Ihnken, Stephen M. Wildhirt, Bruno Reichart, Costas Schulze, Georg Enders
Publikováno v:
Transplant International. 13:S203-S211
Optimal preservation of the myocardium remains a major concern in clinical and experimental heart transplantation. The present study compared the efficacy of University of Wisconsin (UW) and Celsior preservation solution with respect to myocardial pe