Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Costas Lyssiotis"'
Autor:
Nina Steele, Valerie Irizarry-Negron, Veerin Sirihorachai, Samantha Kemp, Eileen Carpenter, Christopher Halbrook, Costas Lyssiotis, Filip Bednar, Timothy Frankel, Benjamin Allen, Marina Pasca di Magliano
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 16-16 (2019)
OBJECTIVES/SPECIFIC AIMS: Pancreatic ductal adenocarcinoma (PDA) has a dismal 5-year survival rate of 9%, making this disease one of the deadliest human malignancies (https://seer.cancer.gov/). Primary barriers to the treatment of pancreatic cancer i
Externí odkaz:
https://doaj.org/article/3b0782830ba34ba69ee4cdfe2afd683f
Autor:
H. Carlo Maurer, Alvaro Curiel-Garcia, Sam Holmstrom, Pasquale Laise, Carmine F. Palermo, Steven A. Sastra, Anthony Andren, Zhang Li, Tessa LeLarge, Irina Sagalovskiy, Daniel R. Ross, Vilma Rosario, Kate Lu, Ethan Ferraiuolo, Nicholas Spinosa, Winston Wong, Kaitlin Shaw, John A. Chabot, Jeanine Genkinger, Hanina Hibshoosh, Gulam A. Manji, Alina Iuga, Roland M. Schmid, Michael A. Badgley, Kristen Johnson, Andrea Califano, Costas Lyssiotis, Kenneth P. Olive
Publikováno v:
bioRxiv
SummaryTo identify novel drivers of malignancy in pancreatic ductal adenocarcinoma (PDAC), we employed regulatory network analysis, which calculates the activity of transcription factors and other regulatory proteins based on the integrated expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c8188e0f70d30874fd610f18de581
https://europepmc.org/articles/PMC10055246/
https://europepmc.org/articles/PMC10055246/
Autor:
Daniel Kremer, Costas Lyssiotis
Publikováno v:
Nature Chemical Biology. 18:441-450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91361405c12c0c9944515fedccc25728
https://doi.org/10.1038/s41589-022-00997-6
https://doi.org/10.1038/s41589-022-00997-6
Autor:
Erik R. Peterson, Peter Sajjakulnukit, Andrew Scott, Caleb Heaslip, Costas Lyssiotis, Maria G. Castro, Daniel R. Wahl
Publikováno v:
Cancer Research. 83:2820-2820
Diffuse midline gliomas (DMG) are an aggressive and treatment resistant form of brain cancer in urgent need of new and effective treatment strategies. Radiation therapy (RT) is the standard of care for DMGs, but these tumors often recur locally withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6503a7d6026139d7f02016cc1f17fd
https://doi.org/10.1158/1538-7445.am2023-2820
https://doi.org/10.1158/1538-7445.am2023-2820
Abstract 1160: A machine learning based method for in-vivo metabolic flux analysis of patient tumors
Autor:
Anjali Mittal, Andrew Scott, Abhinav Achreja, Vijay Tarnal, Wajd Al-Holou, Costas Lyssiotis, Daniel Wahl, Deepak Nagrath
Publikováno v:
Cancer Research. 83:1160-1160
Metabolic fluxes likely control cancer phenotypes and treatment responses but cannot be measured in cancers in human patients. Machine learning has become a popular tool to study cancer biology and can identify complex patterns in the data which may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e88c756c62b14e5227b0e5a97e0f5aa
https://doi.org/10.1158/1538-7445.am2023-1160
https://doi.org/10.1158/1538-7445.am2023-1160
Autor:
Eric Martens, Gabriel Pereira, Marie Boudaud, Mathis Wolter, Celeste Alexander, Alessandro De Sciscio, Erica Grant, Bruno Caetano Trindade, Nicholas Pudlo, Shaleni Singh, Austin Campbell, Mengrou Shan, Li Zhang, Stéphanie Willieme, Kwi Kim, Trisha Denike-Duval, André Bleich, Thomas Schmidt, Lucy Kennedy, Costas Lyssiotis, Grace Chen, Kathryn Eaton, Mahesh Desai
Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of spontaneous intestinal inflammation and is increasing in industrialized populations. Combined with host genetic predisposition, diet and gut bacteria are thought to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1845b26d703fc0aa79b953f8cbfa35bb
https://doi.org/10.1101/2022.04.03.486886
https://doi.org/10.1101/2022.04.03.486886
Autor:
Yoshie Umemura, Yilun Sun, Larry Junck, Denise Leung, Michelle Kim, Wajd Al-Holou, Jason Heth, Oren Sagher, Matthew Schipper, Costas Lyssiotis, Bernard Marini, Theodore Lawrence, Daniel Wahl
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e389b7da4e02d34fc9ee8f40ef59f5
https://doi.org/10.14791/btrt.2022.10.f-1199
https://doi.org/10.14791/btrt.2022.10.f-1199
Autor:
Roshan Kumar, Aaron Landry, Arkajit Guha, Victor Vitvitsky, Ho Lee, Seike Keisuke, Pavan Reddy, Costas Lyssiotis, Ruma Banerjee
Publikováno v:
Journal of Biological Chemistry. 299:103929
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2406d711969a0ffebb4bd6b12f0ea2bb
https://doi.org/10.1016/j.jbc.2023.103929
https://doi.org/10.1016/j.jbc.2023.103929
Autor:
Yoshie Umemura, Wajd Al-Holou, Bernard Marini, Denise Leung, Michelle Kim, Sean Ferris, Larry Junck, Oren Sagher, Jason Heth, Yilun Sun, Matthew Schipper, Costas Lyssiotis, Theodore Lawrence, Daniel Wahl
Publikováno v:
Neuro-Oncology. 24:vii79-vii79
BACKGROUND Purine metabolism promotes glioblastoma growth, stemness, invasiveness, and treatment resistance. The purine synthesis inhibitor, mycophenolate mofetil (MMF), improves radiation and temozolomide efficacy in preclinical glioblastoma models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::083e99f53848b5c58b78997e8ea599b1
https://doi.org/10.1093/neuonc/noac209.300
https://doi.org/10.1093/neuonc/noac209.300
Autor:
Brian Van Tine, Costas Lyssiotis
Publikováno v:
Clin Cancer Res
PURPOSE: Early diagnosis of cancer is critical for improving patient outcomes, but cancers may be hard to diagnose if patients present with non-specific signs and symptoms. We have previously shown that NMR metabolomics analysis can detect cancer in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbbe33e565e85d905459348fc969f91
https://doi.org/10.1158/1078-0432.ccr-21-4180
https://doi.org/10.1158/1078-0432.ccr-21-4180