DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Autor: David J. Porteous, Mostafa Kabiri, Hazel Davidson-Smith, David Price, Marion Bonneau, Daniel L. McCartney, Miles D. Houslay, Paul Perry, J. Kirsty Millar, Kyriakos D. Economides, Shaun Mackie, Laura C. Murphy, Michel Didier, Fumiaki Ogawa, H. Greg Polites, Stephen M. Lawrie, Ellen Grünewald, Barbara Duff, Kathryn L. Evans, Colin A. Semple, Shane T. O’Sullivan, Darragh K. Crummie, Mandy Johnstone, Helen S. Torrance, Jonathan Phillips, Andrew M. McIntosh, Elise L.V. Malavasi, Philippe Gautier, Karen Burr, Costas Constantinides, Susan Anderson, Paraskevi Makedonopoulou, Siddharthan Chandran, Douglas Blackwood, Hannah Murdoch, Matthew Pearson

Publikováno v: Malavasi, E L V, Economides, K D, Grünewald, E, Makedonopoulou, P, Gautier, P, Mackie, S, Murphy, L C, Murdoch, H, Crummie, D, Ogawa, F, McCartney, D L, O'Sullivan, S T, Burr, K, Torrance, H S, Phillips, J, Bonneau, M, Anderson, S M, Perry, P, Pearson, M, Constantinides, C, Davidson-Smith, H, Kabiri, M, Duff, B, Johnstone, M, Polites, H G, Lawrie, S M, Blackwood, D H, Semple, C A, Evans, K L, Didier, M, Chandran, S, McIntosh, A M, Price, D J, Houslay, M D, Porteous, D J & Millar, J K 2018, ' DISC1 regulates N-methyl-D-aspartate receptor dynamics : abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness ', Translational Psychiatry, vol. 8, no. 1, 184 . https://doi.org/10.1038/s41398-018-0228-1
Malavasi, E L V, Economides, K D, Grünewald, E, Makedonopoulou, P, Gautier, P, Mackie, S, Murphy, L C, Murdoch, H, Crummie, D, Ogawa, F, McCartney, D L, O’Sullivan, S T, Burr, K, Torrance, H S, Phillips, J, Bonneau, M, Anderson, S M, Perry, P, Pearson, M, Constantinides, C, Davidson-Smith, H, Kabiri, M, Duff, B, Johnstone, M, Polites, H G, Lawrie, S M, Blackwood, D H, Semple, C A, Evans, K L, Didier, M, Chandran, S, McIntosh, A M, Price, D J, Houslay, M D, Porteous, D J & Millar, J K 2018, ' DISC1 regulates N-methyl-D-aspartate receptor dynamics : abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness ', Translational psychiatry, vol. 8, no. 1, 184 . https://doi.org/10.1038/s41398-018-0228-1
Translational Psychiatry
Translational Psychiatry, Vol 8, Iss 1, Pp 1-16 (2018)

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-Methyl-D-Aspartate receptors (N

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